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Clinton J. Grubbs
University of Alabama
89Publications
29H-index
3,030Citations
Publications 89
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#1Zhijun CaoH-Index: 10
#2Mark Steven MillerH-Index: 27
Last.Richard D. BegerH-Index: 34
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Metabolomics is an effective approach to characterize the metabotype which can reflect the influence of genetics, physiological status, and environmental factors such as drug intakes, diet. Diet may change the chemopreventive efficacy of given agents due to the altered physiological status of the subject. Here, metabolomics response to a chemopreventive agent targretin or tamoxifen, in rats with methylnitrosourea-induced tumors on a standard diet (4% fat, CD) or a high fat diet (21% fat, HFD) wa...
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#1Barbara K. DunnH-Index: 22
Last.Clinton J. GrubbsH-Index: 29
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#1Mark Steven MillerH-Index: 27
#2Clinton J. GrubbsH-Index: 29
Last.Ronald A. LubetH-Index: 62
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#1Barbara K. DunnH-Index: 22
#2Chen SuenH-Index: 1
Last.Clinton J. GrubbsH-Index: 29
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This review focuses on our efforts to translate a low-toxicity retinoid X receptor-selective agonist, UAB30, to the clinic for the prevention of breast cancers. The review is divided into several sections. First, the current status of breast cancer prevention is discussed. Next, preclinical studies are presented that support translation of rexinoids to the clinic for cancer prevention. While current FDAapproved retinoids and rexinoids demonstrate profound effects in treating cancers, they lack s...
5 CitationsSource
#2Clinton J. GrubbsH-Index: 29
Last.Lubet RaH-Index: 14
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The methylnitrosourea(MNU)-induced model of ER + mammary cancers in female Sprague-Dawley rats has been routinely used in our laboratories for screening chemopreventive agents. We recently reported that metformin was ineffective in preventing mammary cancers in this model when given to rats on a standard diet (Thompson, et al, Cancer Prev Res. 2015;8:231-9). In this study, we evaluated metformin in rats placed on either standard diet (4% fat) or a Western diet (20% fat, low calcium). As fat calo...
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#1Clinton J. GrubbsH-Index: 29
#2Mark Steven MillerH-Index: 27
Last.Ronald A. LubetH-Index: 62
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#1Brandy M. Heckman-Stoddard (NIH: National Institutes of Health)H-Index: 10
#2Clinton J. Grubbs (UA: University of Alabama)H-Index: 29
Last.Ronald A. Lubet (NIH: National Institutes of Health)H-Index: 62
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Core needle biopsy, fine needle aspiration, or imaging (e.g., mammography) are currently used to examine chemopreventive agent efficacy in Phase II breast cancer trials. However, biomarker endpoints, such as proliferation rates using Ki67 in normal or "at risk" breast tissue, have not been formally validated relative to cancer outcome. The aim of this study was to validate Ki-67 in "normal" mammary tissue from the methylnitrosourea (MNU) rat mammary tumor model with mammary cancer multiplicity w...
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#2Gang XiaH-Index: 6
Last.Donald D. MuccioH-Index: 20
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(2E,4E,6Z,8E)-8-(3′,4′-Dihydro-1′(2′H)-naphthalen-1′-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid, 9cUAB30, is a selective rexinoid that displays substantial chemopreventive capacity with little toxicity. 4-Methyl-UAB30, an analogue of 9cUAB30, is a potent RXR agonist but caused increased lipid biosynthesis unlike 9cUAB30. To evaluate how methyl substitution influenced potency and lipid biosynthesis, we synthesized four 9cUAB30 homologues with methyl substitutions at the 5-, 6-, 7-, or 8-positi...
11 CitationsSource
#1Ronald A. LubetH-Index: 62
#2Margie L. ClapperH-Index: 36
Last.Clinton J. GrubbsH-Index: 29
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