Eun Kyung Choi
University of Ulsan
Publications 150
#1Joohee Jung (Duksung Women's University)H-Index: 9
#2Do Young Song (UOU: University of Ulsan)
Last.Eun Kyung Choi (UOU: University of Ulsan)H-Index: 23
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RH1 (2, 5-diaziridinyl-3-(hydroxymethy)-6-methyl-1, 4-benzoquinone) is a bioreductive anticancer drug. The mechanism underlying its therapeutic properties has not yet been elucidated. In this study, we aimed to determine whether RH1 exerts its anticancer effect via p53-mediated apoptosis and senescence in vitro and in vivo. RH1 displayed dose-dependent biphasic effects in vitro, i.e., it induced apoptosis at higher dose and senescence at lower dose accompanied by marked activation of p53. Thus, ...
#1Moon-Taek ParkH-Index: 11
#2Eun-Taex OhH-Index: 14
Last.Heon Joo ParkH-Index: 33
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#1KyoungJun YoonH-Index: 5
#2Chiyoung JeongH-Index: 6
Last.Sangwook LeeH-Index: 29
view all 10 authors...
#1Intae Park (KAIST)H-Index: 8
#2Hannah Yang (KAIST)H-Index: 3
Last.Eun Kyung Choi (Asan Medical Center)H-Index: 23
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Purpose Several clinical trials have combined antiangiogenic agents and radiation therapy (RT), but evidence of its clinical benefit is insufficient. In this study, we rationalized and investigated the combination of vascular endothelial growth factor-Grab (VEGF-Grab), an antiangiogenic drug that inhibits VEGF-A and placental growth factor (PlGF) and radiotherapy for anti-cancer therapy. Methods and Materials To observe for changes in PlGF after radiation, HCT116, HCT15, SW480, BxPC3, and RAW264...
#1Eun Kyung ChoiH-Index: 23
#2Jeong-A LimH-Index: 1
Last.Sang Soo KimH-Index: 21
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Germline BRCA1 mutations predispose women to breast and ovarian cancer. BRCA1, a large protein with multiple functional domains, interacts with numerous proteins involved in many important biological processes and pathways. However, to date, the role of BRCA1 interactions at specific stages in the progression of mammary tumors, particularly in relation to cell cycle regulation, remains elusive. Here, we demonstrate that BRCA1 interacts with cyclin B1, a crucial cell cycle regulator, and that the...
1 CitationsSource
#1Hyekyun ChungH-Index: 3
#2Jinhong JungH-Index: 2
Last.Byungchul ChoH-Index: 21
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#1Kyoung Jin Lee (KU: Korea University)H-Index: 40
#2Serk In Park (KU: Korea University)H-Index: 18
Last.Eun Kyung Choi (Asan Medical Center)H-Index: 23
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Neoadjuvant radiotherapy is becoming an important therapeutic option for colorectal cancer (CRC) patients, although complete tumor response is observed only in 20 to 30% patients. However, precise biologic mechanisms underlying resistance to radiotherapy remain to be elucidated. In this study, we established a radiotherapy-resistant CRC patient-derived xenograft (PDX) mouse model, and we discovered that low-density lipoprotein receptor-related protein-1 (LRP-1) is increased in radiotherapy-resis...
#1Sang Eun Park (Asan Medical Center)H-Index: 2
#2Ha-Gyeong Kim (Asan Medical Center)H-Index: 1
Last.Choung-Soo Kim (Asan Medical Center)H-Index: 31
view all 9 authors...
Backgrounds Since most patients with castration-resistant prostate cancer (CRPC) develop resistance to its standard therapy docetaxel, many studies have attempted to identify novel combination treatment to meet the large clinical unmet need. In this study, we examined whether histone deacetylase inhibitors (HDACIs) enhanced the effect of docetaxel on AR signaling in CRPC cells harboring AR and its splice variants. Methods HDACIs (vorinostat and CG200745) were tested for their ability to enhance ...
2 CitationsSource
#1Joohee Jung (Duksung Women's University)H-Index: 12
#2Masaharu Somiya (Osaka University)H-Index: 7
Last.Shun'ichi Kuroda (Osaka University)H-Index: 39
view all 5 authors...
Abstract Bio-nanocapsules (BNCs) consisting of hepatitis B virus surface antigen (HBsAg) L proteins and phospholipids are used as efficient non-viral carriers for liver-specific delivery of genes and drugs. Considering the administration to HB vaccinees and HB patients, endogenous anti-HBsAg immunoglobulins (HBIGs) may reduce the delivery efficacy and prevent repetitive administration. Therefore, low immunogenic BNCs were generated by inserting two point mutations in the HBsAg L protein, which w...