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Hong Boon Lee
University of Malaya
Drug carrierNanocarriersChemistrySinglet oxygenDrug deliveryDoxorubicin
17Publications
7H-index
252Citations
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Publications 18
Newest
#1Shie Yin NgH-Index: 2
#2Anyanee Kamkaew (Suranaree University of Technology)H-Index: 2
Last. Hong Boon LeeH-Index: 10
view all 9 authors...
Abstract Active targeting compound, a non-iodinated derivative of IK-IK-I2-azaBODIPY (1a) was previously reported to preferentially bind melanoma over healthy cells. In this study, we evaluate the photodynamic therapy (PDT) efficiency on melanoma cells of 1a, together with its reversed sequence compound KI-KI-I2-azaBODIPY (1b) and a non-targeted control I2-azaBODIPY-NH2 (2). All three test compounds possess absorption wavelengths in the near-infrared (NIR) region (λmax between 678 and 687 nm) wh...
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#1Chin Siang Kue (Management and Science University)H-Index: 4
#2Shie Yin Ng (UM: University of Malaya)H-Index: 2
Last. Hong Boon Lee (UM: University of Malaya)H-Index: 7
view all 7 authors...
BODIPYs are photosensitizers activatable by light to generate highly reactive singlet oxygen (1O2) from molecular oxygen, leading to tissue damage in the photoirradiated region. Despite their extraordinary photophysical characteristics, they are not featured in clinical photodynamic therapy. This review discusses the recent advances in the design and/or modifications of BODIPYs since 2013, to improve their potential in photodynamic cancer therapy and related areas.
16 CitationsSource
#1Ampornphan Siriviriyanun (NTUST: National Taiwan University of Science and Technology)H-Index: 6
#2Ya-Ju Tsai (NTUST: National Taiwan University of Science and Technology)H-Index: 2
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 10 authors...
Abstract In this study, nanohybrid materials consisting of graphene oxide (GO), β‑cyclodextrin (CD) and poly(amido amine) dendrimer (DEN) were successfully prepared by covalent bonding. GO-CD and GO-CD-DEN were found to be potential nanocarriers for anticancer drugs including chemotherapeutics (doxorubicin (DOX), camptothecin (CPT)) and photosensitizer (protoporphyrin IX (PpIX)). GO-CD possessed 1.2 times higher DOX-loading capacity than GO due to inclusion of additional DOX to the CD. The drug ...
6 CitationsSource
#1Wen Shang Saw (UM: University of Malaya)H-Index: 3
#2Masaki Ujihara (NTUST: National Taiwan University of Science and Technology)H-Index: 8
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 9 authors...
Abstract Physiochemical changes, including size, are known to affect gold nanoparticle cellular internalization and treatment efficacy. Here, we report the effect of four sizes of cystine/citric acid-coated confeito-like gold nanoparticles (confeito-AuNPs) (30, 60, 80 and 100 nm) on cellular uptake, intracellular localization and photothermal anticancer treatment efficiency in MDA-MB231 breast cancer cells. Cellular uptake is size dependent with the smallest size of confeito-AuNPs (30 nm) having...
11 CitationsSource
#1Siaw Fui Kiew (UM: University of Malaya)H-Index: 3
#2Yan Teck Ho (NUS: National University of Singapore)H-Index: 4
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 7 authors...
We synthesized a dextrin (DEX)-conjugated graphene oxide (GO) nanocarrier (GO 100 -DEX) as a potential drug delivery system to respond to a tumor-associated stimulus, α-amylase, that has high permeability through the fenestrated endothelial barrier to the tumor site. At acidic pH and in the presence of α-amylase to simulate tumor conditions, GO 100 -DEX released a 1.5-fold higher amount of doxorubicin (DOX) than of GO 100 . Under the same conditions, the cytotoxic effects of GO 100 -DEX/DOX were...
3 CitationsSource
#1Siew Hui Voon (UM: University of Malaya)H-Index: 6
#2Chin Siang Kue (UM: University of Malaya)H-Index: 4
Last. Shin-ichi Yusa (University of Hyogo)H-Index: 29
view all 8 authors...
Abstract Previously reported amphiphilic diblock copolymer with pendant dendron moieties (P 71 D 3 ) has been further evaluated in tumor-bearing mice as a potential drug carrier. This P 71 D 3 -based micelle of an average diameter of 100 nm was found to be biocompatible, non-toxic and physically stable in colloidal system up to 15 days. It enhanced the in vitro potency of doxorubicin (DOX) in 4T1 breast tumor cells by increasing its uptake, by 3-fold, compared to free DOX. In 4T1 tumor-bearing m...
3 CitationsSource
#1Yu-Hsuan Hsu (NTUST: National Taiwan University of Science and Technology)H-Index: 2
#2Hui-Ling Hsieh (NTUST: National Taiwan University of Science and Technology)H-Index: 1
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 12 authors...
We functionalized graphene oxide (GO) with cyclodextrin (CD) to increase the drug loading and cellular uptake of GO, and bound the GO-CD to carbon-coated iron nanoparticles (Fe@C) with superparamagnetic properties for potential magnetic-directed drug delivery and as a diagnostic agent. The GO-CD/Fe@C was loaded with an anticancer drug, doxorubicin (DOX), to form a multifunctional GO-CD/Fe@C/DOX nanohybrid. A cumulative increase in DOX loading was observed probably due to DOX adsorption to the gr...
3 CitationsSource
#1Hoay Yan Cheah (UM: University of Malaya)H-Index: 3
#2Lik Voon Kiew (UM: University of Malaya)H-Index: 11
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 7 authors...
While nano-sized construct (NSC) use in medicine has grown significantly in recent years, reported unwanted side effects have raised safety concerns. However, the toxicity of NSCs to the cardiovascular system (CVS) and the relative merits of the associated evaluation methods have not been thoroughly studied. This review discusses the toxicological profiles of selected NSCs and provides an overview of the assessment methods, including in silico, in vitro, ex vivo and in vivo models and how they a...
4 CitationsSource
#1Lik Voon Kiew (UM: University of Malaya)H-Index: 11
#2Hoay Yan Cheah (UM: University of Malaya)H-Index: 3
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 11 authors...
Abstract In photodynamic therapy (PDT), the low absorptivity of photosensitizers in an aqueous environment reduces singlet oxygen generation efficiency and thereby decreases photosensitizing efficacy in biological conditions. To circumvent this problem, we designed a phthalocyanine-poly-L-glutamic acid conjugate ( 1-PG ) made from a new phthalocyanine ( Pc 1 ) monofunctionalized to allow adequate conjugation to PGA. The resulting 1-PG conjugate retained high absorptivity in the near-infrared (NI...
7 CitationsSource
#1Derya TopkayaH-Index: 6
#2Shie Yin Ng (UM: University of Malaya)H-Index: 2
Last. Fabienne Dumoulin (GIT: Gebze Institute of Technology)H-Index: 17
view all 7 authors...
In this study, we focus on is the enhancement of singlet oxygen generation, which can be promoted by the introduction of heavy atoms on the photosensitizer. Metalation of tetrapyrrole core by heavy atoms such as platinum or palladium is another option but these metals tend to aggravate the aggregation tendency of the macrocycle. Halogenation proved to be much more successful on photosensitizing phthalocyanine [1] and BOPDIPY [2]. Besides, our recent systematic study on monohalogenated trihydroxy...
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