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Soo Young Choi
UPRRP College of Natural Sciences
113Publications
23H-index
1,625Citations
Publications 105
Newest
#1Woosuk KimH-Index: 20
#2Su Bin ChoH-Index: 7
Last.Seung Myung MoonH-Index: 11
view all 11 authors...
In a previous study, we utilized a proteomic approach and found a significant reduction in phosphatidylethanolamine-binding protein 1 (PEBP1) protein level in the spinal cord at 3 h after ischemia. In the present study, we investigated the role of PEBP1 against oxidative stress in NSC34 cells in vitro, and ischemic damage in the rabbit spinal cord in vivo. We generated a PEP-1-PEBP1 fusion protein to facilitate the penetration of blood-brain barrier and intracellular delivery of PEBP1 protein. T...
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#1Joon Ha ParkH-Index: 17
#2Ji Hyeon AhnH-Index: 12
Last.Soo Young ChoiH-Index: 23
view all 17 authors...
A brief episode of transient ischemia (TI) can confer cerebral ischemic tolerance against a subsequent severer TI under standard condition. The brain under obesity’s conditions is more sensitive to ischemic injury. However, the impact of a brief episode of TI under obesity’s conditions has not been fully addressed yet. Thus, the objective of this study was to determine the effect of a brief TI in the hippocampus of high-fat diet (HFD)-induced obese gerbils and related mechanisms. Gerbils were ma...
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#2Daewon KimH-Index: 16
Last.Soo Young ChoiH-Index: 23
view all 8 authors...
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#1Bai Hui ChenH-Index: 9
#2Joon Ha ParkH-Index: 17
Last.Ji Hyeon AhnH-Index: 12
view all 22 authors...
Melatonin is known to improve cognitive deficits, and its functions have been studied in various disease models, including Alzheimer’s disease. In this study, we investigated effects of melatonin on cognition and the cholinergic system of the septum and hippocampus in a mouse model of scopolamine-induced amnesia. Scopolamine (1 mg/kg) and melatonin (10 mg/kg) were administered intraperitoneally to mice for 2 and 4 weeks. The Morris water maze and passive avoidance tests revealed that both treatm...
5 CitationsSource
#1Joon Ha ParkH-Index: 17
#2Yang Hee KimH-Index: 4
Last.Choong Hyun LeeH-Index: 24
view all 11 authors...
Abstract Atomoxetine has been widely used for the treatment of attention-deficit/ hyperactivity disorder. ATX has additional abilities such as antagonistic effects on the N-methyl-Daspartate receptors (NMDARs) and benefit effects in some animal models of neurological disorders. However, there were few studies regarding protective effects and related mechanisms of ATX against cerebral ischemic insults. The objective of this study is to investigate neuroprotection of ATX pretreatment and its mecha...
3 CitationsSource
#1Soo Yeon AnH-Index: 2
#2Gi Soo YounH-Index: 10
Last.Jinseu ParkH-Index: 32
view all 5 authors...
6 CitationsSource
#1Hyun Sook HwangH-Index: 13
#2In Young ParkH-Index: 3
Last.Hyun KimH-Index: 21
view all 4 authors...
Background: The protein transduction domain (PTD) enables therapeutic proteins to directly penetrate the membranes of cells and tissues, and has been increasingly
3 CitationsSource
#1Hyo Sang JoH-Index: 11
#2Duk-Soo KimH-Index: 21
Last.Soo Young ChoiH-Index: 23
view all 17 authors...
4 CitationsSource
Reactive oxygen species generated under oxidative stress are involved in neuronal diseases, including ischemia. Glutathione S-transferase pi (GSTpi) is a member of the GST family and is known to play important roles in cell survival. We investigated the effect of GSTpi against oxidative stress-induced hippocampal HT-22 cell death, and its effects in an animal model of ischemic injury, using a cell-permeable PEP-1-GSTpi protein. PEP-1-GSTpi was transduced into HT-22 cells and significantly protec...
2 CitationsSource
#1Ah Ra GohH-Index: 9
#2Gi Soo YounH-Index: 10
Last.Jinseu ParkH-Index: 32
view all 9 authors...
Abstract Abnormal expression of pro-inflammatory mediators such as cell adhesion molecules and cytokines has been implicated in various inflammatory skin diseases, including atopic dermatitis. In this study, we investigated the anti-inflammatory activity of Aronia melanocarpa concentrate (AC) and its action mechanisms using in vivo and in vitro skin inflammation models. Topical application of AC on mouse ears significantly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema f...
5 CitationsSource
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