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Michael B. Ware
Emory University
Tumor microenvironmentPancreatic stellate cellCytokinePancreatic cancerCancer researchMedicineImmune system
4Publications
1H-index
1Citations
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Publications 8
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#1Michael B. Ware (Emory University)H-Index: 1
#2Christopher McQuinn (OSU: Ohio State University)H-Index: 3
Last. Jacob S. Bowers (MUSC: Medical University of South Carolina)H-Index: 8
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Abstract: Pancreatic ductal adenocarcinoma (PDAC) is exceptionally resistant to immune checkpoint inhibition (ICI). We previously reported that elevated systemic interleukin-6 (IL-6) and increased numbers of T cells positive for circulating cytotoxic T-lymphocyte-associated protein 4 (CTLA 4) correlate with worse overall survival in patients with PDAC. We postulated that combined blockade of IL-6 and CTLA-4 would significantly enhance anti-tumor immune responses to PDAC. Dual blockade of IL-6 an...
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#1Matthew R. Farren (Emory University)H-Index: 2
#1Matthew R. FarrenH-Index: 5
Last. Gregory B. LesinskiH-Index: 29
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Pancreatic ductal adenocarcinoma (PDAC) has dismal 5-year survival (<9%). We hypothesize that exposure of tumors to conventional therapies may preferentially modulate immune biomarkers in the tumor microenvironment in PDAC. PDAC patients who underwent upfront surgical resection or who received neoadjuvant FOLFIRINOX with or without neoadjuvant radiotherapy followed by surgical resection were selected for study. Total expression of immunologically relevant transcripts and spatially resolved expre...
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#1Michael B. Ware (Emory University)H-Index: 1
Last. Gregory B. LesinskiH-Index: 29
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Pancreatic ductal adenocarcinoma (PDAC) is rarely detected early, instead presenting in patients as advanced metastatic disease once symptoms are evident. Given the central role of metastasis in pancreatic tumor progression and mortality, there is an urgent need for further investigation of how PDAC metastasizes and for novel treatment strategies targeting PDAC metastasis. A prominent histopathologic feature of PDAC is a desmoplastic, fibrotic stroma consisting of extracellular matrix components...
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#1Michael B. Ware (Emory University)H-Index: 1
#2Christopher McQuinn (OSU: Ohio State University)H-Index: 3
Last. Gregory B. Lesinski (Emory University)H-Index: 29
view all 11 authors...
Immune checkpoint blockade therapy has shown promise in many cancers. However, pancreatic ductal adenocarcinoma (PDAC) has proven refractory to most targeted and immune-based therapies. Previous research by our group and others demonstrated immune suppression in PDAC driven by activated fibroblasts, known as pancreatic stellate cells (PSCs). Specifically, our lab has demonstrated expansion of myeloid-derived suppressor cells (MDSCs) by PSCs in an interleukin-6 (IL-6) and STAT3 dependent manner (...
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#1Michael B. WareH-Index: 1
#2Mehmet AkceH-Index: 2
Last. Gregory B. LesinskiH-Index: 29
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#1Mohammad Y. Zaidi (Emory University)H-Index: 4
#2Yuchen Zhang (Emory University)
Last. Gregory B. Lesinski (Emory University)H-Index: 29
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Pancreatic ductal adenocarcinoma (PDAC) has a prominent fibrotic stroma, which is a result of interactions between tumor, immune and pancreatic stellate cells (PSC). Prior work from our laboratory has defined a role for stroma-derived cytokines such as IL-6 as a significant barrier restraining immunity against PDAC. Our group is pursuing novel approaches to target pathways in the tumor microenvironment (TME), in an effort to improve access of effector immune cells to PDAC and response to immunot...
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#1Thomas A. Mace (OSU: Ohio State University)H-Index: 14
#2Micheal B. Ware (Emory University)H-Index: 1
Last. Gregory B. Lesinski (Emory University)H-Index: 29
view all 12 authors...
Soybeans are a rich source of isoflavones that have been linked with anti-inflammatory processes and various health benefits. However, specific mechanisms whereby soy bioactives impact immune cell subsets are unclear. Isoflavones, such as genistein and daidzein, are metabolized by microbes to bioactive metabolites as O-desmethylangolensin (O-DMA) and equol, whose presence has been linked to health benefits. We examined how soy isoflavones and metabolites impact natural killer (NK) cell signaling...
1 CitationsSource
#1Mohammad Y. ZaidiH-Index: 4
#2Michael B. WareH-Index: 1
Last. Gregory B. LesinskiH-Index: 29
view all 11 authors...
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