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Xuefei Yu
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Last.Mark WalkerH-Index: 82
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Introduction: Age-related cumulative mitochondrial mutations can cause mitochondrial dysfunction. The mitochondrial DNA mutator mouse (PolgA mut/mut ) is a model of premature ageing and has been previously shown to develop impaired insulin secretion with age. Methods: Immunofluorescence was used to study mitochondrial respiratory chain protein expression (complex I and IV) and the cell composition in islets. Experiments were conducted on pancreas tissue from PolgA mut/mut mice and age-matched wi...
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