Riccardo E. Marioni
University of Edinburgh
Publications 226
#1Robert F. Hillary (Edin.: University of Edinburgh)H-Index: 3
#2Anna J. Stevenson (Edin.: University of Edinburgh)H-Index: 3
Last.Andrew M. McIntosh (Edin.: University of Edinburgh)H-Index: 75
view all 14 authors...
Individuals of the same chronological age display different rates of biological ageing. A number of measures of biological age have been proposed which harness age-related changes in DNA methylation profiles. These include methylation-based predictors of chronological age (HorvathAge, HannumAge), all-cause mortality (DNAm PhenoAge, DNAm GrimAge) and telomere length (DNAm Telomere Length). In this study, we test the association between these epigenetic markers of ageing and the prevalence and inc...
#1Kyle J.J. McLachlan (Edin.: University of Edinburgh)H-Index: 1
#2James H. ColeH-Index: 23
Last.Catharine R. GaleH-Index: 60
view all 6 authors...
Objective To investigate whether people with more positive attitudes to ageing are biologically younger as defined by leucocyte telomere length, accelerated DNA methylation GrimAge (AgeAccelGrim) and brain-predicted age difference, and whether these biomarkers explain relationships between attitudes to ageing and mortality. Methods We used linear regression to examine cross-sectionally attitudes to ageing (measured using the Attitudes to Ageing Questionnaire) and the three biomarkers in 758 adul...
#2Futao ZhangH-Index: 12
Last.Archie CampbellH-Index: 24
view all 22 authors...
#2Futao ZhangH-Index: 12
Last.Riccardo E. MarioniH-Index: 40
view all 22 authors...
Availability of Data and Material According to the terms of consent for GS participants, access to individual-level data (omics and phenotypes) must be reviewed by the GS Access Committee. Applications should be made to Full summary statistics for the analyses presented are publicly available online at Funding GS received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the S...
#1Robert F. Hillary (Edin.: University of Edinburgh)H-Index: 3
#2Anna J. Stevenson (Edin.: University of Edinburgh)H-Index: 3
Last.Riccardo E. Marioni (Edin.: University of Edinburgh)H-Index: 40
view all 23 authors...
Individuals of the same chronological age exhibit disparate rates of biological ageing. Consequently, a number of methodologies have been proposed to determine biological age and primarily exploit variation at the level of DNA methylation (DNAm). A novel epigenetic clock, termed ‘DNAm GrimAge’ has outperformed its predecessors in predicting the risk of mortality as well as many age-related morbidities. However, the association between DNAm GrimAge and cognitive or neuroimaging phenotypes remains...
2 CitationsSource
#1Yanni Zeng (Edin.: University of Edinburgh)H-Index: 6
#2Carmen Amador (Edin.: University of Edinburgh)H-Index: 7
Last.Chris Haley (Edin.: University of Edinburgh)H-Index: 59
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Parent-of-origin effects (POE) exist when there is differential expression of alleles inherited from the two parents. A genome-wide scan for POE on DNA methylation at 639,238 CpGs in 5,101 individuals identifies 733 independent methylation CpGs potentially influenced by POE at a false discovery rate ≤ 0.05 of which 331 had not previously been identified. Cis and trans methylation quantitative trait loci (mQTL) regulate methylation variation through POE at 54% (399/733) of the identified POE-infl...
3 CitationsSource
#1Jesper Lund (University of Southern Denmark)H-Index: 2
#2Shuxia Li (University of Southern Denmark)H-Index: 10
Last.Qihua Tan (University of Southern Denmark)H-Index: 32
view all 11 authors...
Background Multiple epigenome-wide association studies have been performed to identify DNA methylation patterns regulated by aging or correlated with risk of death. However, the inter-relatedness of the epigenetic basis of aging and mortality has not been well investigated.
3 CitationsSource
#1Christopher G. Bell (QMUL: Queen Mary University of London)H-Index: 23
#2Robert Lowe (QMUL: Queen Mary University of London)H-Index: 17
Last.Vardhman K. Rakyan (QMUL: Queen Mary University of London)H-Index: 34
view all 21 authors...
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating interventions. Here, we discuss key challenges to understand clock mechanisms and biomarker utility. This requires dissecting the drivers and regulators of ...
12 CitationsSource
#1Gail Davies (Edin.: University of Edinburgh)H-Index: 52
#2Max LamH-Index: 10
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 222 authors...
Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.
1 CitationsSource
#1Janie Corley (Edin.: University of Edinburgh)H-Index: 30
#2Simon R. Cox (Edin.: University of Edinburgh)H-Index: 20
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 10 authors...
Recent advances in genome-wide DNA methylation (DNAm) profiling for smoking behaviour have given rise to a new, molecular biomarker of smoking exposure. It is unclear whether a smoking-associated DNAm (epigenetic) score has predictive value for ageing-related health outcomes which is independent of contributions from self-reported (phenotypic) smoking measures. Blood DNA methylation levels were measured in 895 adults aged 70 years in the Lothian Birth Cohort 1936 (LBC1936) study using the Illumi...