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Clara-Louisa Sandmann
Max Delbrück Center for Molecular Medicine
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#1Sebastiaan van Heesch (MDC: Max Delbrück Center for Molecular Medicine)
#2Franziska Witte (MDC: Max Delbrück Center for Molecular Medicine)
Last.Norbert HubnerH-Index: 57
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Summary Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. Here, we analyze the translatomes of 80 human hearts to identify new translation events and quantify the effect of translational regulation. We show extensive translational control of cardiac gene expression, which is orchestrated in a process-specific manner. Translation downstream of predicted disease-causing protein-truncating variants appears to be fre...
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