Alberto Mills
Spanish National Research Council
ChemistryTrypanosoma bruceiRNA-dependent RNA polymeraseBiochemistryStereochemistry
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Publications 7
#1Clara Herrera-Arozamena (CSIC: Spanish National Research Council)H-Index: 5
#2Martin H. Estrada-Valencia (CSIC: Spanish National Research Council)H-Index: 1
Last. Rafael León (UAM: Autonomous University of Madrid)H-Index: 22
view all 17 authors...
Abstract New multi-target indole and naphthalene derivatives containing the oxadiazolone scaffold as a bioisostere of the melatonin acetamido group have been developed. The novel compounds were characterized at melatonin receptors MT1R and MT2R, quinone reductase 2 (QR2), lipoxygenase-5 (LOX-5), and monoamine oxidases (MAO-A and MAO-B), and also as radical scavengers. We found that selectivity within the oxadiazolone series can be modulated by modifying the side chain functionality and co-planar...
#1Alberto Mills (University of Alcalá)
#2Federico Gago (University of Alcalá)H-Index: 36
Bending of double-stranded (ds) DNA plays a crucial role in many important biological processes and is relevant for nanotechnological applications. Among all the elements that have been studied in relation to dsDNA bending, A-tracts stand out as one of the most controversial. The “ApA wedge” theory was disproved when a series of linear polynucleotides containing phased 5′-A4T4-3′ or 5′-T4A4-3′ runs were shown to be bent or straight, respectively, and crystallographic evidence revealed that A-tra...
#1Alejandro HorgaH-Index: 8
#2Cathy E. WoodwardH-Index: 13
Last. Michael G. HannaH-Index: 63
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Pyruvate dehydrogenase complex (PDC) deficiency caused by mutations in the X-linked PDHA1 gene has a broad clinical presentation, and the pattern of X-chromosome inactivation has been proposed as a major factor contributing to its variable expressivity in heterozygous females. Here, we report the first set of monozygotic twin females with PDC deficiency, caused by a novel, de novo heterozygous missense mutation in exon 11 of PDHA1 (NM_000284.3: c.1100A>T). Both twins presented in infancy with a ...
#1Jon Del ArcoH-Index: 4
#2Alberto Mills (CSIC: Spanish National Research Council)
Last. Jesús Fernández-Lucas (Grupo México)H-Index: 12
view all 4 authors...
#1Pedro A. Sánchez-Murcia (University of Alcalá)H-Index: 8
#2Alberto Mills (University of Alcalá)
Last. Federico Gago (University of Alcalá)H-Index: 36
view all 4 authors...
Many natural products target mammalian tubulin but only a few can form a covalent bond and hence irreversibly affect microtubule function. Among them, zampanolide (ZMP) and taccalonolide AJ (TAJ) stand out, not only because they are very potent antitumor agents but also because the adducts they form with β-tubulin have been structurally characterized in atomic detail. By applying model building techniques, molecular orbital calculations, molecular dynamics simulations and hybrid QM/MM methods, w...
#1Sonia de CastroH-Index: 16
Last. María-José CamarasaH-Index: 31
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Foot-and-mouth disease virus (FMDV) is an RNA virus belonging to the Picornaviridae family that contains three small viral proteins (VPgs), named VPg1, VPg2 and VPg3, linked to the 5′-end of the viral genome. These VPg proteins act as primers for RNA replication, which is initiated by the consecutive binding of two UMP molecules to the hydroxyl group of Tyr3 in VPg. This process, termed uridylylation, is catalyzed by the viral RNA-dependent RNA polymerase named 3Dpol. 5-Fluorouridine triphosphat...
Last. Wei-Shuo FangH-Index: 18
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A series of novel 7,9-O-linked macrocyclic taxoids together with modification at the C2 position were synthesized, and their cytotoxicities against drug-sensitive and P-glycoprotein and βIII-tubulin overexpressed drug-resistant cancer cell lines were evaluated. It is demonstrated that C-seco taxoids conformationally constrained via carbonate containing-linked macrocyclization display increased cytotoxicity on drug-resistant tumors overexpressing both βIII and P-gp, among which compound 22b, bear...