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Ming Jing
Liaoning University of Traditional Chinese Medicine
LiposomeVasculogenic mimicryDaunorubicinCancer researchBreast cancer
2Publications
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Publications 7
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#1Xue-Min Yao (LNUTCM: Liaoning University of Traditional Chinese Medicine)
Last. Xin-Ze Liu (LNUTCM: Liaoning University of Traditional Chinese Medicine)
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Tumor invasion and metastasis are the nodus of anti-tumor. Epithelial cell-mesenchymal transition is widely regarded as one of the key steps in the invasion and metastasis of breast cancer. In this study, GGP modified daunorubicin plus dioscin liposomes are constructed and characterized. GGP modified daunorubicin plus dioscin liposome has suitable particle size, narrow PDI, zeta potential of about -5 mV, long cycle effect, and enhanced cell uptake due to surface modification of GGP making the li...
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#1Xue-Tao Li (LNUTCM: Liaoning University of Traditional Chinese Medicine)H-Index: 6
#2Ming Jing (LNUTCM: Liaoning University of Traditional Chinese Medicine)
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AbstractTumor metastasis is a major cause of cancer treatment failure and death, and chemotherapy efficiency for gastric cancer patients is usually unsatisfactory due to tumor cell metastasis, poor...
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#1Fu-Yi Cai (LNUTCM: Liaoning University of Traditional Chinese Medicine)
#2Xue-Min Yao (LNUTCM: Liaoning University of Traditional Chinese Medicine)
Last. Xue-Tao Li (LNUTCM: Liaoning University of Traditional Chinese Medicine)H-Index: 6
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Non-small cell lung cancer (NSCLC) is a malignant cancer characterized by easy invasion, metastasis and poor prognosis, so that conventional chemotherapy can't inhibit its invasion and metastasis. Doxorubicin, as a broad-spectrum antitumor drug, cannot be widely used in clinic because of its poor targeting, short half-life, strong toxicity and side effects. Therefore, the aim of our study is to construct a kind of PFV modified doxorubicin plus schisandrin B liposomes to solve the above problems,...
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#1Ming Jing (LNUTCM: Liaoning University of Traditional Chinese Medicine)
Last. Si-Yu He (LNUTCM: Liaoning University of Traditional Chinese Medicine)
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As a malignant tumor, breast cancer is very prone to metastasis. Chemotherapy is one of the most common means for treating breast cancer. However, due to the serious metastasis and the poor targeting effect of traditional chemotherapeutic drugs, even after years of efforts, the therapeutic effect is still unsatisfied. Therefore, in this study, we constructed a kind of PFV modified epirubicin plus schisandrin B liposomes to solve the above disadvantages. In vitro experiments showed that the targe...
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#1Min Fu (LNUTCM: Liaoning University of Traditional Chinese Medicine)H-Index: 2
Last. Rui-Jun Ju (BIPT: Beijing Institute of Petrochemical Technology)H-Index: 3
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AbstractConventional treatment fails to completely eliminate highly invasive breast cancer cells, and most surviving breast cancer cells tend to reproliferate and metastasize by forming vasculogeni...
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#1Liang Kong (LNUTCM: Liaoning University of Traditional Chinese Medicine)
#2Fu-Yi Cai (LNUTCM: Liaoning University of Traditional Chinese Medicine)
Last. Xue-Tao Li (LNUTCM: Liaoning University of Traditional Chinese Medicine)H-Index: 6
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Chemotherapy for non-small cell lung cancer (NSCLC) is far from satisfactory, mainly due to poor targeting of antitumor drugs and self-adaptations of the tumors. Angiogenesis, vasculogenic mimicry (VM) channels, migration, and invasion are the main ways for tumors to obtain nutrition. Herein, RPV-modified epirubicin and dioscin co-delivery liposomes were successfully prepared. These liposomes showed ideal physicochemical properties, enhanced tumor targeting and accumulation in tumor sites, and i...
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#1Jing-jing Liu (LNUTCM: Liaoning University of Traditional Chinese Medicine)H-Index: 2
Last. Rui-Jun Ju (BIPT: Beijing Institute of Petrochemical Technology)H-Index: 3
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AbstractPresently, there are no few anticancer drugs that have been used clinically due to their poor targeting ability, short half-life period, non-selective distributions, generation of vasculogenic mimicry (VM) channels, high metastasis, and high recurrence rate. This study aimed to explore the effects of R8 modified epirubicin–dihydroartemisinin liposomes that could target non-small-cell lung cancer (NSCLC) cells, destroy VM channels, inhibit tumor metastasis, and explain the possible underl...
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