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Juan Francisco Calderón Giadrosic
Johns Hopkins University School of Medicine
Cell signalingProtein kinase CEhlers–Danlos syndromePathogenesisMAPK/ERK pathway
2Publications
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Publications 2
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#1Caitlin J. Bowen (HHMI: Howard Hughes Medical Institute)
#1Caitlin J. Bowen (HHMI: Howard Hughes Medical Institute)
Last. Harry C. DietzH-Index: 90
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Vascular Ehlers-Danlos syndrome (vEDS) is an autosomal-dominant connective tissue disorder caused by heterozygous mutations in the COL3A1 gene, which encodes the pro-alpha 1 chain of collagen III. Loss of structural integrity of the extracellular matrix is believed to drive the signs and symptoms of this condition, including spontaneous arterial dissection and/or rupture, the major cause of mortality. We created 2 mouse models of vEDS that carry heterozygous mutations in Col3a1 that encode glyci...
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#1Caitlin J. Bowen (HHMI: Howard Hughes Medical Institute)
#2Juan Francisco Calderón Giadrosic (JHUSOM: Johns Hopkins University School of Medicine)
Last. Harry C. Dietz (HHMI: Howard Hughes Medical Institute)H-Index: 90
view all 8 authors...
Vascular Ehlers-Danlos Syndrome (vEDS) is an autosomal-dominant connective tissue disorder caused by heterozygous mutations in the COL3A1 gene. Currently, loss of structural integrity of the extracellular matrix is believed to drive the signs and symptoms of this condition, including spontaneous arterial dissection and/or rupture, the major cause of mortality. Using novel mouse models of vEDS that carry heterozygous Col3a1 glycine substitutions, we show that signaling abnormalities in the PLC/IP...
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