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Osamu Sekine
Shiga University of Medical Science
EndocrinologyAdipose tissueEicosapentaenoic acidDocosahexaenoic acidBiology
8Publications
7H-index
265Citations
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Publications 8
Newest
#1Keiko Kondo (Shiga University of Medical Science)H-Index: 9
#2Katsutaro Morino (Shiga University of Medical Science)H-Index: 26
Last. Hiroshi Maegawa (Shiga University of Medical Science)H-Index: 48
view all 12 authors...
Abstract Objective The beneficial effects of fish and n-3 polyunsaturated fatty acids (PUFAs) consumption on atherosclerosis have been reported in numerous epidemiological studies. However, to the best of our knowledge, the effects of a fish-based diet intervention on endothelial function have not been investigated. Therefore, we studied these effects in postmenopausal women with type 2 diabetes mellitus (T2DM). Materials/Methods Twenty-three postmenopausal women with T2DM were assigned to two f...
26 CitationsSource
#1Keiko Kondo (Shiga University of Medical Science)H-Index: 9
#2Atsushi Ishikado (Shiga University of Medical Science)H-Index: 15
Last. Atsunori Kashiwagi (Shiga University of Medical Science)H-Index: 66
view all 18 authors...
Abstract Periodontal disease is related to aging, smoking habits, diabetes mellitus, and systemic inflammation. However, there remains limited evidence about causality from intervention studies. An effective diet for prevention of periodontal disease has not been well established. The current study was an intervention study examining the effects of a high-fiber, low-fat diet on periodontal disease markers in high-risk subjects. Forty-seven volunteers were interviewed for recruitment into the stu...
26 CitationsSource
#1Satoshi Ugi (Shiga University of Medical Science)H-Index: 26
#2Shiro MaedaH-Index: 39
Last. Hiroshi Maegawa (Shiga University of Medical Science)H-Index: 48
view all 13 authors...
Objective The aim of this study was to search for novel markers of visceral adiposity. Methods Visceral (omental) and subcutaneous adipose tissues were obtained from 43 Japanese men. Microarray analysis using total RNA from visceral and subcutaneous adipose tissues obtained from five men with abdominal obesity and five nonobese men was first conducted. Then the expression pattern of candidate genes identified in the human study in mouse models of adiposity was examined. Results Among 30,500 gene...
5 CitationsSource
#1Fumiyuki Nakagawa (Shiga University of Medical Science)H-Index: 7
#2Katsutaro Morino (Shiga University of Medical Science)H-Index: 26
Last. Hiroshi Maegawa (Shiga University of Medical Science)H-Index: 48
view all 15 authors...
Abstract It has recently been reported that expression of heme oxygenase-1 (HO-1) plays a protective role against many diseases. Furthermore, n-3 polyunsaturated fatty acids (PUFAs) were shown to induce HO-1 expression in several cells in vitro, and in a few cases also in vivo. However, very few reports have demonstrated that n-3 PUFAs induce HO-1 in vivo. In this study, we examined the effect of fish-oil dietary supplementation on the distribution of fatty acids and their peroxidative metabolit...
21 CitationsSource
#1Atsushi Ishikado (Shiga University of Medical Science)H-Index: 15
#2Katsutaro Morino (Shiga University of Medical Science)H-Index: 26
Last. Hiroshi Maegawa (Shiga University of Medical Science)H-Index: 48
view all 18 authors...
Recent studies have proposed that n-3 polyunsaturated fatty acids (n-3 PUFAs) have direct antioxidant and anti-inflammatory effects in vascular tissue, explaining their cardioprotective effects. However, the molecular mechanisms are not yet fully understood. We tested whether n-3 PUFAs showed antioxidant activity through the activation of nuclear factor erythroid 2-related factor 2 (Nrf2), a master transcriptional factor for antioxidant genes. C57BL/6 or Nrf2−/− mice were fed a fish-oil diet for...
43 CitationsSource
#1Masateru Ushio (Shiga University of Medical Science)H-Index: 1
#2Yoshihiko Nishio (Kadai: Kagoshima University)H-Index: 37
Last. Hiroshi Maegawa (Shiga University of Medical Science)H-Index: 48
view all 11 authors...
Nonalcoholic fatty liver disease is the most frequent liver disease. Ezetimibe, an inhibitor of intestinal cholesterol absorption, has been reported to ameliorate hepatic steatosis in human and animal models. To explore how ezetimibe reduces hepatic steatosis, we investigated the effects of ezetimibe on the expression of lipogenic enzymes and intestinal lipid metabolism in mice fed a high-fat or a high-fructose diet. CBA/JN mice were fed a high-fat diet or a high-fructose diet for 8 wk with or w...
24 CitationsSource
#1Chisato Kusunoki (Shiga University of Medical Science)H-Index: 4
#2Liu Yang (Shiga University of Medical Science)H-Index: 1
Last. Hiroshi Maegawa (Shiga University of Medical Science)H-Index: 48
view all 12 authors...
Abstract Oxidative stress is produced in adipose tissue of obese subjects and has been associated with obesity-related disorders. Recent studies have shown that omega-3 polyunsaturated fatty acid (ω3-PUFA) has beneficial effects in preventing atherosclerotic diseases and insulin resistance in adipose tissue. However, the role of ω3-PUFA on adipocytes has not been elucidated. In this study, 3T3-L1 adipocytes were treated with ω3-PUFA and its metabolites, eicosapentaenoic acid (EPA), docosahexaeno...
52 CitationsSource
#1Takeshi Yoshizaki (Shiga University of Medical Science)H-Index: 18
#2Chisato Kusunoki (Shiga University of Medical Science)H-Index: 4
Last. Hiroshi Maegawa (Shiga University of Medical Science)H-Index: 48
view all 12 authors...
Autophagy is an essential process for both the maintenance and the survival of cells, with homeostatic low levels of autophagy being critical for intracellular organelles and proteins. In insulin resistant adipocytes, various dysfunctional/damaged molecules, organelles, proteins, and end-products accumulate. However, the role of autophagy (in particular, whether autophagy is activated or not) is poorly understood. In this study we found that in adipose tissue of insulin resistant mice and hypert...
68 CitationsSource
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