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Marc Siggel
Max Planck Society
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#1Marc Siggel (MPG: Max Planck Society)
#2Ramachandra M. Bhaskara (MPG: Max Planck Society)H-Index: 7
Last.Gerhard Hummer (Goethe University Frankfurt)H-Index: 67
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#1Sören von Bülow (MPG: Max Planck Society)H-Index: 1
#2Marc Siggel (MPG: Max Planck Society)
Last.Gerhard Hummer (Goethe University Frankfurt)H-Index: 67
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We develop a detailed description of protein translational and rotational diffusion in concentrated solution on the basis of all-atom molecular dynamics simulations in explicit solvent. Our systems contain up to 540 fully flexible proteins with 3.6 million atoms. In concentrated protein solutions (100 mg/mL and higher), the proteins ubiquitin and lysozyme, as well as the protein domains third IgG-binding domain of protein G and villin headpiece, diffuse not as isolated particles, but as members ...
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