Michael A. Trembley
Boston Children's Hospital
Publications 2
#1Karyn M. Austin (Boston Children's Hospital)H-Index: 11
#2Michael A. Trembley (Boston Children's Hospital)H-Index: 1
Last.William T. Pu (Harvard University)H-Index: 59
view all 7 authors...
Arrhythmogenic cardiomyopathy is a genetic disorder characterized by the risk of life-threatening arrhythmias, myocardial dysfunction and fibrofatty replacement of myocardial tissue. Mutations in genes that encode components of desmosomes, the adhesive junctions that connect cardiomyocytes, are the predominant cause of arrhythmogenic cardiomyopathy and can be identified in about half of patients with the condition. However, the molecular mechanisms leading to myocardial destruction, remodelling ...
5 CitationsSource
#1Cameron S. Brand (UCSD: University of California, San Diego)H-Index: 6
#2Janet K. Lighthouse (UR: University of Rochester)H-Index: 2
Last.Michael A. Trembley (Boston Children's Hospital)H-Index: 1
view all 3 authors...
Abstract Heart failure is the leading cause of morbidity and mortality worldwide. Several lines of evidence suggest that physical activity and exercise can pre-condition the heart to improve the response to acute cardiac injury such as myocardial infarction or ischemia/reperfusion injury, preventing the progression to heart failure. It is becoming more apparent that cardioprotection is a concerted effort between multiple cell types and converging signaling pathways. However, the molecular mechan...
1 CitationsSource