Andrew M. Prentice
University of London
Publications 599
#1James H. Cross (Lond: University of London)H-Index: 1
#2Ousman Jarjou (Lond: University of London)
Last.Carla Cerami (Lond: University of London)H-Index: 16
view all 7 authors...
Abstract Background Neonates, particularly those born preterm (PTB) and with low birthweight (LBW), are especially susceptible to bacterial and fungal infections that cause an estimated 225,000 deaths annually. Iron is a vital nutrient for the most common organisms causing septicaemia. Full-term babies elicit an immediate postnatal hypoferremia assumed to have evolved as an innate defence. We tested whether PTB and LBW babies are capable of the same response. Methods We conducted an observationa...
#1Sarah H. AtkinsonH-Index: 13
Last.James A. BerkleyH-Index: 41
view all 22 authors...
#1Martha MwangomeH-Index: 11
#2Helen M. NabweraH-Index: 5
Last.Andrew M. PrenticeH-Index: 88
view all 3 authors...
#1Laura Katus (University of Cambridge)
#2Luke Mason (Birkbeck, University of London)H-Index: 3
Last.Saikou DrammehH-Index: 2
view all 17 authors...
Abstract Introduction Infants and children in low- and middle-income countries are frequently exposed to a range of poverty-related risk factors, increasing their likelihood of poor neurodevelopmental outcomes. There is a need for culturally objective markers, which can be used to study infants from birth, thereby enabling early identification and ultimately intervention during a critical time of neurodevelopment. Method In this paper, we investigate developmental changes in auditory event relat...
#2Jasper V. Been (Edin.: University of Edinburgh)H-Index: 21
Last.Stefan Unger (Edin.: University of Edinburgh)H-Index: 6
view all 8 authors...
Background Accurate and timely data on the health of a population are key for evidence-based decision making at both the policy and programmatic level. In many low-income settings, such data are unavailable or outdated. Using an electronic medical records system, we determined the association between nutritional status and severe illness and mortality among young children presenting to a rural primary health care facility in the Gambia.
#1Sarah J Zyba (UC Davis: University of California, Davis)
#2Rita Wegmüller (ETH Zurich)H-Index: 20
Last.K. Ryan Wessells (UC Davis: University of California, Davis)H-Index: 12
view all 7 authors...
#1Martha Mwangome (Wellcome Trust)H-Index: 11
#2Andrew M. Prentice (Lond: University of London)H-Index: 88
The term ‘double burden of malnutrition’ is usually interpreted in terms of the physical status of children: stunted and wasted children on the one hand and overweight/obese children on the other. There is a third category of malnutrition that can occur at either end of the anthropometric spectrum or, indeed, in children whose physical size may be close to ideal. This third type is most commonly articulated with the phrase ‘hidden hunger’ and is often illustrated by micronutrient deficiencies; t...
#1Chathura Gunasekara (BCM: Baylor College of Medicine)H-Index: 3
#2C. Anthony Scott (BCM: Baylor College of Medicine)H-Index: 3
Last.Robert A. Waterland (BCM: Baylor College of Medicine)H-Index: 35
view all 19 authors...
DNA methylation is thought to be an important determinant of human phenotypic variation, but its inherent cell type specificity has impeded progress on this question. At exceptional genomic regions, interindividual variation in DNA methylation occurs systemically. Like genetic variants, systemic interindividual epigenetic variants are stable, can influence phenotype, and can be assessed in any easily biopsiable DNA sample. We describe an unbiased screen for human genomic regions at which interin...
3 CitationsSource
#1Sarah Prentice (Lond: University of London)H-Index: 3
#2Amadou T. Jallow (Lond: University of London)H-Index: 2
Last.Andrew M. Prentice (Lond: University of London)H-Index: 88
view all 9 authors...
Septicemia is a leading cause of death among neonates in low-income settings, a situation that is deteriorating due to high levels of antimicrobial resistance. Novel interventions are urgently needed. Iron stimulates the growth of most bacteria and hypoferremia induced by the acute phase response is a key element of innate immunity. Cord blood, which has high levels of hemoglobin, iron and transferrin saturation, has hitherto been used as a proxy for the iron status of neonates. We investigated ...
1 CitationsSource
#1Leanne K. KüpersH-Index: 10
#2Claire Monnereau (EUR: Erasmus University Rotterdam)H-Index: 6
Last.Janine F. Felix (EUR: Erasmus University Rotterdam)H-Index: 33
view all 127 authors...
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10−7). In additi...
3 CitationsSource