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Valentina Gatta
University of Bologna
VirologyTropismOncolytic virusBiologyCancer cell
6Publications
4H-index
62Citations
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Publications 6
Newest
#1Valerio LeoniH-Index: 8
#2Biljana PetrovicH-Index: 5
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3 CitationsSource
#1Biljana PetrovicH-Index: 5
#2Valerio LeoniH-Index: 8
view all 6 authors...
3 CitationsSource
#1Valerio Leoni (UNIBO: University of Bologna)H-Index: 8
#2Valentina Gatta (UNIBO: University of Bologna)H-Index: 4
Last. Gabriella Campadelli-Fiume (UNIBO: University of Bologna)H-Index: 41
view all 6 authors...
7 CitationsSource
#1Biljana Petrovic (UNIBO: University of Bologna)H-Index: 5
#2Tatiana Gianni (UNIBO: University of Bologna)H-Index: 15
Last. Gabriella Campadelli-Fiume (UNIBO: University of Bologna)H-Index: 41
view all 4 authors...
15 CitationsSource
#2Biljana PetrovicH-Index: 5
Last. Valentina GattaH-Index: 4
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Most of the oncolytic herpes simplex viruses (HSVs) exhibit a high safety profile achieved through attenuation. They carry defects in virulence proteins that antagonize host cell response to the virus, including innate response, apoptosis, authophagy, and depend on tumor cell proliferation. They grow robustly in cancer cells, provided that these are deficient in host cell responses, which is often the case. To overcome the attenuation limits, a strategy is to render the virus highly cancer-speci...
14 CitationsSource
#1Valentina Gatta (UNIBO: University of Bologna)H-Index: 4
#2Biljana Petrovic (UNIBO: University of Bologna)H-Index: 5
Last. Gabriella Campadelli-Fiume (UNIBO: University of Bologna)H-Index: 41
view all 3 authors...
Herpes simplex virus (HSV) enters cells by means of four essential glycoproteins - gD, gH/gL, gB, activated in a cascade fashion by gD binding to one of its receptors, nectin1 and HVEM. We report that the engineering in gH of a heterologous ligand – a single-chain antibody (scFv) to the cancer-specific HER2 receptor – expands the HSV tropism to cells which express HER2 as the sole receptor. The significance of this finding is twofold. It impacts on our understanding of HSV entry mechanism and th...
20 CitationsSource
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