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Julian Grünewald
Harvard University
RNA editingCytosineCytidine deaminaseAPOBEC3ARNA
3Publications
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#2Ronghao Zhou (Harvard University)H-Index: 2
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CRISPR-Cas base editor technology enables targeted nucleotide alterations and is being rapidly deployed for research and potential therapeutic applications1,2. The most widely used base editors induce DNA cytosine (C) deamination with rat APOBEC1 (rAPOBEC1) enzyme, which is targeted by a linked Cas protein-guide RNA (gRNA) complex3,4. Previous studies of cytosine base editor (CBE) specificity have identified off-target DNA edits in human cells5,6. Here we show that a CBE with rAPOBEC1 can cause ...
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