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Diana G. Bohannon
Eastern Virginia Medical School
ImmunologySonic hedgehogEncephalitisBiologyHedgehog signaling pathway
5Publications
2H-index
5Citations
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Publications 4
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#1Diana G. Bohannon (EVMS: Eastern Virginia Medical School)H-Index: 2
#2Yueying Wang (EVMS: Eastern Virginia Medical School)
Last. Woong-Ki Kim (EVMS: Eastern Virginia Medical School)H-Index: 17
view all 11 authors...
We previously showed that rhesus macaques neonatally infected with simian immunodeficiency virus (SIV) do not develop SIV encephalitis (SIVE) and maintain low brain viral loads despite having similar plasma viral loads compared to SIV-infected adults. We hypothesize that differences in myeloid cell populations that are the known target of SIV and HIV in the brain contribute to the lack of neonatal susceptibility to lentivirus-induced encephalitis. Using immunohistochemistry and immunofluorescenc...
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#1Antonito T. Panganiban (Tulane University)H-Index: 4
#2Robert V. Blair (Tulane University)H-Index: 4
Last. Woong-Ki Kim (EVMS: Eastern Virginia Medical School)H-Index: 17
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Zika virus (ZIKV) is a neurotropic virus that can cause neuropathy in adults and fetal neurologic malformation following infection of pregnant women. We used a nonhuman primate model, the Indian-origin Rhesus macaque (IRM), to gain insight into virus-associated hallmarks of ZIKV-induced adult neuropathy. We find that the virus causes prevalent acute and chronic neuroinflammation and chronic disruption of the blood-brain barrier (BBB) in adult animals. Infection results in significant, targeted, ...
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#1Elizabeth C. Delery (Tulane University)H-Index: 3
#2Diana G. Bohannon (EVMS: Eastern Virginia Medical School)H-Index: 2
Last. Woong-Ki Kim (EVMS: Eastern Virginia Medical School)H-Index: 17
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Despite combination antiretroviral therapies making HIV a chronic rather than terminal condition for many people, the prevalence of HIV-associated neurocognitive disorders (HAND) is increasing. This is especially problematic for children living with HIV. Children diagnosed HAND rarely display the hallmark pathology of HIV encephalitis in adults, namely infected macrophages and multinucleated giant cells in the brain. This finding has also been documented in rhesus macaques infected perinatally w...
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#1Diana G. Bohannon (EVMS: Eastern Virginia Medical School)H-Index: 2
#2Allen Ko (EVMS: Eastern Virginia Medical School)H-Index: 2
Last. Woong-Ki Kim (EVMS: Eastern Virginia Medical School)H-Index: 17
view all 5 authors...
Background Impairment of the blood–brain barrier (BBB) has been associated with cognitive decline in many CNS diseases, including HIV-associated neurocognitive disorders (HAND). Recent research suggests an important role for the Sonic hedgehog (Shh) signaling pathway in the maintenance of BBB integrity under both physiological and pathological conditions.
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