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Mohammed F. Aldawsari
SolubilityActivity coefficientChemistryLactideDissolution
3Publications
1H-index
5Citations
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Publications 8
Newest
Abstract In the pharmaceutical industry, the systematic optimization of formulation using Quality by Design (QbD) approach is economic, highly precise and ensures product quality. The current endeavor was aimed to prepare escitalopram ultra-fast melting tablets (UFMTs) based on QbD approach using suspension spray-coating technique. The (32) full factorial design was applied to obtain the optimal formulation in terms of; mannitol level (X1) and partially pre-gelatinized starch level (PPGS; X2) as...
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#1Md. Khalid AnwerH-Index: 7
#1Md. Khalid AnwerH-Index: 10
Last. Muzaffar Iqbal (KSU: King Saud University)H-Index: 12
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Abstract In the current study, solubility, thermodynamics and molecular interaction of delafloxacin (DFLX) in water, ethanol, transcutol-HP (THP) and three different alkylimidazolium based ionic liquids were conducted at temperature range “T = 298.2 K to 318.2 K” and pressure “p = 0.1 MPa”. The solid phase characterization of initial and equilibrated DFLX by DSC, FTIR and PXRD confirmed no significant change in crystallinity of the drug. The maximum mole fraction solubility of DFLX at “T = 318.2...
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#1M. M. MuharramH-Index: 6
#2Ashraf T. Abulhamd (Al-Azhar University)H-Index: 2
Last. Nikolaos E. LabrouH-Index: 29
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Given the worldwide increase in antibiotic resistant bacteria, bacteriophage derived endolysins represent a very promising new alternative class of antibacterials in the fight against infectious diseases. Endolysins are able to degrade the prokaryotic cell wall, and therefore have potential to be exploited for biotechnological and medical purposes. Staphylococcus epidermidis is a Gram-positive multidrug-resistant (MDR) bacterium of human skin. It is a health concern as it is involved in nosocomi...
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#1Md. Khalid AnwerH-Index: 7
#1Md. Khalid AnwerH-Index: 10
Last. Faisal Imam (KSU: King Saud University)H-Index: 11
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Delafloxacin (DFL) is a novel potent and broad-spectrum fluoroquinolone group of antibiotics effective against both Gram-positive and negative aerobic and anaerobic bacteria. In this study, DFL-loaded stearic acid (lipid) chitosan (polymer) hybrid nanoparticles (L-P-NPs) have been developed by single-emulsion-solvent evaporation technique. The mean particle size and polydispersity index (PDI) of optimized DFL-loaded L-P-NPs (F1-F3) were measured in the range of 299-368 nm and 0.215-0.269, respec...
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The purpose of the currents study was to enhance bioavailability of rivaroxaban (RXB) and reduce the food effect. RXB loaded PLGA nanoparticles (RXB-PLGA-NPs) were prepared by emulsion solvent evaporation method and optimized using central composite design (CDD). The optimized RXB-PLGA-NPs (F8) with composition, PLGA (125 mg), PVA (0.5%w/w) and RXB (20 mg) was found optimum with particle size (496 ± 8.5 nm), PDI (0.607), ZP (− 18.41 ± 3.14 mV), %EE (87.9 ± 8.6) and %DL (9.5 ± 1.6). The optimized...
1 CitationsSource
The aim of the study was to prepare lansoprazole (LNS)-loaded poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles in order to improve the physicochemical stability associated with LNS. We synthesized LNS-loaded PLGA nanoparticles in the presence of magnesium oxide as alkalizer to improve the release of LNS and stability against photodegradation. The LNS-encapsulated PLGA nanoparticles were developed by the nanoprecipitation/solvent evaporation method, resulting in a particle size of 246.7 ± 3.4 ...
1 CitationsSource
#1Md. Khalid AnwerH-Index: 10
#2Mohammad MuqtaderH-Index: 1
Last. Faiyaz ShakeelH-Index: 27
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Estimating the solubility and solution thermodynamics parameters of aliskiren hemifumarate (AHF) in three different room temperature ionic liquids (RTILs), Transcutol-HP (THP) and water are interesting as there is no solubility data available in the literature. In the current study, the solubility and solution thermodynamics of AHF in three different RTILs, THP and water at the temperature range from 298.2 to 318.2 K under air pressure 0.1 MP were evaluated. The solid phase evaluation by Differe...
1 CitationsSource
#1Md. Khalid AnwerH-Index: 10
#2Muqtader MohammadH-Index: 2
Last. Faiyaz Shakeel (KSU: King Saud University)H-Index: 27
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Abstract A key factor in dosage form development is selection of a suitable solvent for the solubility of drugs. Solubility data of osimertinib (OSM) are scarce in the research literature. In current study, thermodynamic solubility of OSM in eight different pharmaceutically useful solvents namely, water, ethanol, propylene glycol (PG), ethyl acetate (EA), isopropyl myristate (IPM), dichloromethane (DCM), Transcutol-HP (THP), and polyethylene glycol-400 (PEG-400) at the temperature from (298.2 to...
4 CitationsSource
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