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Michael Dennis Jensen
University of Rochester
69Publications
27H-index
8,526Citations
Publications 69
Newest
#1Glenn A. GaesserH-Index: 38
Last.Richard J. BloomerH-Index: 31
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You might find this additional info useful...This article cites€34 articles, 25 of which you can access for free at: http://jap.physiology.org/content/89/3/937.full#ref-list-1This article has been cited by€10 other HighWire-hosted articles: http://jap.physiology.org/content/89/3/937#cited-by Updated information and services including high resolution figures, can be found at: http://jap.physiology.org/content/89/3/937.fullAdditional material and information about Journal of Applied Physiology can...
#1Aaron M. Potretzke (UW: University of Wisconsin-Madison)H-Index: 7
#2Meghan Warren (American Physical Therapy Association)H-Index: 15
Last.Michael Dennis JensenH-Index: 27
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Objective: To determine whether insulin resistance is associated with reduced risk of weight gain.Methods: In this retrospective study, we reviewed medical records of volunteers who had undergone a euglycemic, hyperinsulinemic clamp in research studies at Mayo Clinic between October 20, 1986, and January 30, 2002. Data from volunteers who had at least 1 year of followup were analyzed, which included height, weight, date of birth, ethnicity, body composition (percentage body fat and kilograms of ...
#1Yourka D. Tchoukalova (Pennington Biomedical Research Center)H-Index: 9
#2Susanne B. Votruba (Mayo Clinic)H-Index: 18
Last.Michael Dennis JensenH-Index: 68
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Body fat distribution is an important predictor of the metabolic consequences of obesity, but the cellular mechanisms regulating regional fat accumulation are unknown. We assessed the changes in adipocyte size (photomicrographs) and number in response to overfeeding in upper- and lower-body s.c. fat depots of 28 healthy, normal weight adults (15 men) age 29 ± 2 y. We analyzed how these changes relate to regional fat gain (dual energy X-ray absorptiometry and computed tomography) and baseline pre...
Context: An upper body/visceral fat distribution in obesity is closely linked with metabolic complications, whereas increased lower body fat is independently predictive of reduced cardiovascular risk. Evidence Acquisition: The measured functions of different fat depots with regards to fatty acid storage and release in health and obesity were reviewed. The adverse effects of experimentally increasing free fatty acid (FFA) concentrations on liver, muscle, pancreatic β-cell, and endothelial functio...
#1Sylvia Santosa (Mayo Clinic)H-Index: 13
#2Donald D. Hensrud (Mayo Clinic)H-Index: 28
Last.Michael Dennis Jensen (Mayo Clinic)H-Index: 27
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Background: Regional differences in meal fat storage may explain the preservation of fat accumulation in obese persons. Objective: The objective was to determine whether meal fatty acid (FA) metabolism differs by sex and obesity phenotypes before and after weight loss. Design: A [ 3 H]triolein-containing meal was given to trace meal FA oxidation ( 3 H 2 0 generation) and adipose tissue uptake (abdominal subcutaneous and gluteal biopsy samples) in 13 upper-body obese (UOb) men, 9 UOb women, and 8...
#1Kathryn H. Schmitz (UPenn: University of Pennsylvania)H-Index: 58
#2Peter J. Hannan Mstat (UMN: University of Minnesota)H-Index: 73
Last.Michael Dennis Jensen (Mayo Clinic)H-Index: 27
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Background:Americanwomenaged25–44ygain0.5–1kgyearly, most of which is fat. Because few midlife women participate in strength training, this mode of activity may be a novel intervention for preventing age-associated fat increases in this population. Objectives: The primary aim was to assess the efficacy of twiceweekly strength training to avoid increases in percentage body fat and intraabdominal fat. Design: A randomized controlled trial was conducted in an ethnicallydiversesampleof164overweighta...
#1Abel Romero-Corral (UR: University of Rochester)H-Index: 28
#2Virend K. Somers (UR: University of Rochester)H-Index: 96
Last.Francisco Lopez-Jimenez (UR: University of Rochester)H-Index: 51
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Background Emerging evidence suggests that a mildly elevated body mass index (BMI), is related to improved survival and fewer cardiovascular events in patients with coronary artery disease (CAD). We hypothesize that these results are related to the poor diagnostic performance of BMI to detect adiposity, especially in the intermediate BMI ranges. Methods and Results A cross-sectional study of 95 patients with CAD referred to phase II cardiac rehabilitation. Body fat (BF)% was estimated by air dis...
#1Samyah Shadid (Mayo Clinic)H-Index: 8
#2Christina Koutsari (Mayo Clinic)H-Index: 19
Last.Michael Dennis JensenH-Index: 68
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We sought to assess whether direct uptake of circulating free fatty acids (FFAs) by adipocytes occurs in vivo in overnight postabsorptive humans and, if so, whether there are regional differences in uptake between lean and obese women and men. We used bolus injections of radiolabeled FFA tracers followed by carefully timed adipose tissue biopsies. First, we validated a method to measure direct adipocyte FFA uptake and then quantitated this process using the modified methods in normal-weight post...
#1André Scheen (University of Liège)H-Index: 70
#2Nick Finer (University of Cambridge)H-Index: 36
Last.L. Van GaalH-Index: 64
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Insulin regulation of free fatty acid (FFA) release is an important aspect of metabolic function; however, FFA release is exquisitely sensitive to insulin, which complicates the design and analysis of dose response experiments. We measured FFA ([3H]palmitate) and glucose ([3H]glucose) kinetics in 7 nonobese men, 7 nonobese women, 7 obese men, and 7 obese women by using a two-step insulin clamp (0.25 and 2.5 mU/kg fat-free mass per minute). Obese men and women were characterized as having a BMI o...
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