Match!
Qingguo Lu
University of Mississippi Medical Center
AMPKBiochemistrySignal transductionBiologyProtein kinase A
4Publications
3H-index
12Citations
What is this?
Publications 6
Newest
#1Xiaodong Sun (UMMC: University of Mississippi Medical Center)H-Index: 2
#2Fang Han (UMMC: University of Mississippi Medical Center)
Last. Ji Li (USF: University of South Florida)H-Index: 34
view all 9 authors...
Sodium glucose co-transporter-2 inhibitors (SGLT2i) have favorable cardiovascular outcomes in diabetic patients. However, whether SGLT2i can improve obesity-related cardiac dysfunction is unknown. Sestrin2 is a novel stress-inducible protein that regulates AMPK-mTOR and suppresses oxidative damage. The aim of this study was to determine whether empagliflozin (EMPA) improves obesity-related cardiac dysfunction via regulating Sestrin2-mediated pathways in diet-induced obesity. C57BL/6J mice and Se...
Source
#1Qingguo Lu (Sichuan University)H-Index: 3
#2Jia Liu (USF: University of South Florida)H-Index: 3
Last. Ji Li (USF: University of South Florida)H-Index: 34
view all 8 authors...
Abstract The beneficial effects of empagliflozin (EMPA) on cardiac functions during ischemia and reperfusion were characterized. The contractile functions of isolated cardiomyocytes from adult C57BL/6J mice were determined with IonOptix SoftEdgeMyoCam system. The mitochondrial superoxide production was measured by MitoSOX fluorescent probe. The ex vivo isolated heart perfusion system was used to determine the pharmacological effects of EMPA on heart's contractile functions under both physiologic...
3 CitationsSource
#1Jia Liu (USF: University of South Florida)H-Index: 3
#2Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 3
Last. Jiyan Leng (JLU: Jilin University)H-Index: 1
view all 8 authors...
The renin–angiotensin system (RAS) is undisputedly well-studied as one of the oldest and most critical regulators for arterial blood pressure, fluid volume, as well as renal function. In recent studies, RAS has also been implicated in the development of obesity, diabetes, hyperlipidemia, and other diseases, and also involved in the regulation of several signaling pathways such as proliferation, apoptosis and autophagy, and insulin resistance. AMP-activated protein kinase (AMPK), an essential cel...
2 CitationsSource
#1Qingguo Lu (Sichuan University)H-Index: 3
#2Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 3
Last. Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 34
view all 8 authors...
Diabetics have higher morbidity and mortality in cardiovascular disease (CVD). A variety of antidiabetic agents are available for clinical choice. Cardiovascular (CV) safety assessment of these agents is crucial in addition to hypoglycemic effect before clinical prescription. Adenosine 5′-monophosphate-activated protein kinase (AMPK) is an important cell energy sensor, which plays an important role in regulating myocardial energy metabolism, reducing ischemia and ischemia/reperfusion (I/R) injur...
3 CitationsSource
#1Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 3
#2Jia Liu (UMMC: University of Mississippi Medical Center)H-Index: 3
Last. Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 34
view all 9 authors...
6 CitationsSource
#1Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 3
#2Jia Liu (UMMC: University of Mississippi Medical Center)H-Index: 3
Last. Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 34
view all 8 authors...
Heart failure (HF) is a serious disease with high mortality. The incidence of this disease has continued to increase over the past decade. All cardiovascular diseases causing dysfunction of various physiological processes can result in HF. AMP-activated protein kinase (AMPK), an energy sensor, has pleiotropic cardioprotective effects and plays a critical role in the progression of HF. In this review, we highlight that AMPK can not only improve the energy supply in the failing heart by promoting ...
3 CitationsSource
1