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Yoshihisa Yamamoto
Teikyo Heisei University
Analytical chemistryOrganic chemistryChemistryChromatographyActive ingredient
20Publications
5H-index
69Citations
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Publications 23
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Background: The clobetasol propionate cream formulations (CLB Cr ) belong to the "strongest" group, and are used widely. In addition, those formulations are often used as a mixture with moisturizer. Recently, we evaluated pharmaceutical properties of the CLB Cr using near infrared (NIR) spectroscopy, and characteristic NIR spectra depending on the formulation were observed. In the present study, we attempted to evaluate the more diverse pharmaceutical properties of CLB Cr , including the stabili...
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#1Hiroshi Hisada (Meiji Pharmaceutical University)H-Index: 4
#2Akira Okayama (Meiji Pharmaceutical University)
Last. Toshiro Fukami (Meiji Pharmaceutical University)H-Index: 13
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Combination tablets containing multiple active pharmaceutical ingredients (APIs) are expected to improve patient convenience by decreasing the number of tablets to be taken; thus, numerous formulations containing multiple APIs have recently been developed. To allow for dose adjustments based on patient conditions, many tablets have a bisection line to allow equal division of tablets. However, there have been no investigations regarding content uniformity among divided combination tablets. Theref...
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#1Takuya Hoshino (Meiji Pharmaceutical University)
#2Motoshige Azuma (Meiji Pharmaceutical University)H-Index: 1
Last. Toshiro Fukami (Meiji Pharmaceutical University)H-Index: 13
view all 8 authors...
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#2Yoshihisa Yamamoto (Teikyo Heisei University)H-Index: 5
Last. Toshiro Fukami (Meiji Pharmaceutical University)H-Index: 13
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We demonstrated the difference in the distribution state of pharmaceutical ingredients between tacrolimus (TCR) original ointment and six kinds of generic medicines. Two-dimensional imaging and dep...
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#1Yoshihisa Yamamoto (Teikyo Heisei University)H-Index: 5
Last. Tatsuo KoideH-Index: 11
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Abstract We evaluated the three-dimensional distribution of liquid droplets in a droplet dispersion-type ointment using a confocal Raman microscope. In component 1, which extracted the most frequently detected information, although the domains were heterogeneous, domains with high intensity were observed. From the Raman spectrum, it was suggested that this component provided information on the distribution in the ointment base. In component 2, images with dispersed domains with diameters less th...
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#2Toyofumi Suzuki (Nihon University)H-Index: 16
Last. Yoshihisa Yamamoto (Teikyo Heisei University)H-Index: 5
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#1Yoshihisa Yamamoto (Teikyo Heisei University)H-Index: 5
#2Rie Yamauchi (Hoshi University)
Last. Tatsuo KoideH-Index: 11
view all 6 authors...
The poultice formulation is a patch containing a large amount of water. It is known that the water contained in the adhesive polymer layer (ADPL) of poultice affects the cooling sensation and skin permeability of the active pharmaceutical ingredient (API). In this study, we evaluated the relationship between the water content in a ketoprofen poultice formulation and the amount of time the poultice was left out at room temperature after removal from the airtight container, as well as the influenc...
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#1Yoshihisa Yamamoto (Teikyo Heisei University)H-Index: 5
#2Akane Hanai (Teikyo Heisei University)H-Index: 1
Last. Tatsuo KoideH-Index: 11
view all 10 authors...
Abstract Betamethasone butyrate propionate ointment (BBPO) is mainly used for adult patients in dermatology and is often prescribed as a mixture containing a base or moisturizing cream for various reasons. However, in the case of a moisturizing cream, since this formulation is composed of various ingredients, a physical change is expected to occur by mixing it with an ointment. Therefore, in the present study, the physical stability of a mixture of four BBPO formulations and heparinoid oily crea...
2 CitationsSource
#1Motoshige Azuma (Meiji Pharmaceutical University)H-Index: 1
#2Mika Fujii (Meiji Pharmaceutical University)H-Index: 1
Last. Toshiro Fukami (Meiji Pharmaceutical University)H-Index: 13
view all 10 authors...
1 CitationsSource
#1Yoshihisa Yamamoto (Teikyo Heisei University)H-Index: 5
#2Toshiro Fukami (Meiji Pharmaceutical University)H-Index: 13
Last. Tatsuo KoideH-Index: 11
view all 6 authors...
Abstract The purpose of this study is to verify the usefulness of near infrared (NIR) spectroscopy for evaluation of pharmaceutical properties of cream formulations. The present study examined in detail the pharmaceutical properties of clobetasol propionate (CLB) cream formulations using NIR spectroscopy. The characteristic NIR spectrum of Dermovate ® (DRM), the original CLB cream formulation displayed a shoulder around 4800 cm −1 as well as absorption around 5200 cm −1 . A high concentration of...
2 CitationsSource
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