Aaron Klug
Medical Research Council
Molecular biologyChemistryGeneticsDNABiology
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Publications 19
#1Michael MooreH-Index: 2
#2Aaron KlugH-Index: 12
Last. Yen ChooH-Index: 22
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Multizinc finger peptides are likely to reach increased prominence trn in the search for the "ideal" designer transcription factor for in vivo an applications such as gene therapy. However, for these treatments th to be effective and safe, the peptides must bind with high affinity in and, more importantly, with great specificity. Our previous retw search has shown that zinc finger arrays can be made to bind 18 bp gr of DNA with picomolar affinity, but also has suggested that arrays th of fingers...
#1Aaron Klug (Medical Research Council)H-Index: 12
First page of article Keywords: Franklin, Rosalind Elsie (DNA discovery); tobacco mosaic virus
#1Maria Grazia Spillantini (University of Cambridge)H-Index: 64
#2Jill R. Murrell (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 44
Last. Bernardino GhettiH-Index: 80
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Work in 1980s and early 1990s established that the microtubule- associated protein tau is the major component of the paired helical filament of Alzheimer's disease. Similar filamentous deposits are also present in a number of other diseases, including progressive supranuclear palsy,corticobasal degeneration and Pick's disease. In 1998, the relevance of tau dysfunction for the neurodegenerative process became clear, when mutations in the tau gene were found to cause the inherited "frontotemporal ...
10 CitationsSource
#1Gordon H. Orians (UW: University of Washington)H-Index: 41
Last. George M. Woodwell (Woods Hole Research Center)H-Index: 26
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In “Scientists versus Whaling” (BioScience 52:1137–1140), Aron, Burke, and Freeman defend Japan's controversial “scientific” whaling program against a series of criticisms we made in an open letter to the Government of Japan last May in the New York Times. Our letter, signed by 21 eminent scientists, including three Nobel laureates and several pioneers of conservation biology, called on Japan to suspend its whaling program. Aron and his coauthors claim that our letter contains numerous errors of...
#1Aaron Klug (Medical Research Council)H-Index: 12
1920–1958 English physical chemist and X-ray crystallographer who played a key role in the discovery of the three-dimensional structure of DNA. Keywords: DNA; MRC; double helix; X-ray crystallography
#1Yen ChooH-Index: 22
#2Aaron KlugH-Index: 12
#1Yen ChooH-Index: 22
#2Aaron KlugH-Index: 12
Last. Michael MooreH-Index: 2
view all 3 authors...
L'invention concerne un procede pour produire un polypeptide a liaison acide nucleique modifie, ce procede comprenant les etapes suivantes : (a) fournir un polypeptide a liaison acide nucleique comprenant une pluralite de modules a liaison acide nucleique; (b) selectionner un premier domaine de liaison compose d'un ou de deux modules a liaison acide nucleique contigus; (c) selectionner un second domaine de liaison compose d'un ou de deux modules a liaison acide nucleique contigus; et (d) introdu...
#1Luca VaraniH-Index: 21
#1Luca VaraniH-Index: 27
Last. G. VaraniH-Index: 1
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1 CitationsSource
#1Luca Varani (Medical Research Council)H-Index: 27
#2Masato Hasegawa (Medical Research Council)H-Index: 3
Last. Gabriele Varani (Medical Research Council)H-Index: 53
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Coding region and intronic mutations in the tau gene cause frontotemporal dementia and parkinsonism linked to chromosome 17. Intronic mutations and some missense mutations increase splicing in of exon 10, leading to an increased ratio of four-repeat to three-repeat tau isoforms. Secondary structure predictions have led to the proposal that intronic mutations and one missense mutation destabilize a putative RNA stem-loop structure located close to the splice-donor site of the intron after exon 10...
196 CitationsSource
#1Bernardino GhettiH-Index: 80
#2M. G. SpillantiniH-Index: 25
Last. Aaron KlugH-Index: 12
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La presente invention porte en general sur des procedes et des compositions de diagnostic, modelisation et traitement de pathologies de type tau. Cette invention revele notamment que les mutations dans le gene tau provoquent un enchevetrement neurofibrillaire. Plus specifiquement, les mutations geniques qui generent des modifications dans les rapports des isoformes tau donnent lieu a la formation de filaments tau anormaux.