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Mengzhu Liu
Peking University
Cas9Genome editingComputational biologyBiologyCRISPR
2Publications
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Publications 3
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#1Jianhang Yin (PKU: Peking University)H-Index: 1
#2Mengzhu Liu (PKU: Peking University)H-Index: 1
Last. Jiazhi Hu (PKU: Peking University)H-Index: 12
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Efficient and precise genome editing is essential for clinical applications and generating animal models, which requires engineered nucleases with high editing ability while low off-target activity. Here we present a high-throughput sequencing method, primer-extension-mediated sequencing (PEM-seq), to comprehensively assess both editing ability and specificity of engineered nucleases. We showed CRISPR/Cas9-generated breaks could lead to chromosomal translocations and large deletions by PEM-seq. ...
1 CitationsSource
#1Jianhang YinH-Index: 1
#2Mengzhu LiuH-Index: 1
Last. Jiazhi HuH-Index: 12
view all 4 authors...
Source
#1Jianhang YinH-Index: 1
#2Mengzhu LiuH-Index: 1
Last. Jiazhi HuH-Index: 12
view all 4 authors...
Source
1