Philippe Pibarot
Laval University
Publications 79
#1Andras P. Durko (University of Debrecen)H-Index: 1
#2Stuart J. Head (Erasmus University Medical Center)H-Index: 31
Last.Ruggero De PaulisH-Index: 24
view all 20 authors...
Intraoperative surgical prosthetic heart valve (SHV) choice is a key determinant of successful surgery and positive postoperative outcomes. Currently, many controversies exist around the sizing and labelling of SHVs rendering the comparison of different valves difficult. To explore solutions, an expert Valve Labelling Task Force was jointly initiated by the European Association for Cardio-Thoracic Surgery (EACTS), The Society of Thoracic Surgeons (STS) and the American Association for Thoracic S...
#1Tania Rodriguez-Gabella (Laval University)H-Index: 10
#2Luis Nombela-Franco (Hospital Clínico San Carlos)H-Index: 36
Last.Josep Rodés-Cabau (Laval University)H-Index: 68
view all 14 authors...
Controversial data exist on clinical outcomes of patients with paradoxical low-flow, low-gradient aortic stenosis (PLF-LG-AS) undergoing valve replacement. The objective of this study was to determine the clinical outcomes and treatment futility in patients with paradoxical low-flow (PLF), low-gradient (LG) severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI). A total of 493 patients with severe symptomatic AS and preserved ejection fraction (>50%) undergoing TAV...
3 CitationsSource
#1Mohamed-Salah Annabi (Laval University)H-Index: 2
#2Marine Clisson (Laval University)H-Index: 2
Last.Philippe Pibarot (Laval University)H-Index: 42
view all 4 authors...
About 60% of patients with paradoxical low-flow, low-gradient (PLF-LG) aortic stenosis (AS) have a severe disease that justifies aortic valve replacement (AVR). The first step in patients with symptomatic PLF AS should be to rule out measurement errors and treat hypertension. The second step is to distinguish pseudo-severe from true severe AS (TSAS). The third step is to select the optimal treatment modality at the right time. Regarding the second step, projected aortic valve area calculated usi...
#1Henrique B. Ribeiro (Laval University)H-Index: 36
#2Stamatios Lerakis (Emory University Hospital)H-Index: 39
Last.Josep Rodés-Cabau (Laval University)H-Index: 68
view all 31 authors...
Abstract Background Few data exist on patients with low-flow, low-gradient aortic stenosis (LFLG-AS) undergoing transcatheter aortic valve replacement (TAVR). Also, very scarce data exist on the usefulness of dobutamine stress echocardiography (DSE) before TAVR in these patients. Objectives The authors sought to evaluate clinical outcomes and changes in left ventricular ejection fraction (LVEF) following TAVR in patients with classical LFLG-AS. Methods This multicenter registry included 287 pati...
30 CitationsSource
#1Mohamed-Salah Annabi (Laval University)H-Index: 2
#2Eden Touboul (Laval University)H-Index: 1
Last.Marie-Annick Clavel (Laval University)H-Index: 34
view all 14 authors...
Abstract Background In the American College of Cardiology/American Heart Association guidelines, patients are considered to have true-severe stenosis when the mean gradient (MG) is ≥40 mm Hg with an aortic valve area (AVA) ≤1 cm 2 during dobutamine stress echocardiography (DSE). However, these criteria have not been previously validated. Objectives The aim of this study was to assess the value of these criteria to predict the presence of true-severe AS and the occurrence of death in patients wit...
17 CitationsSource
#1Philippe Pibarot (Laval University)H-Index: 42
#2Rebecca T. Hahn (CUMC: Columbia University Medical Center)H-Index: 39
Last.Susheel Kodali (CUMC: Columbia University Medical Center)H-Index: 63
view all 22 authors...
Importance Moderate/severe and even mild paravalvular regurgitation (PVR) are associated with increased mortality following transcatheter aortic valve replacement (TAVR) with first and second generations of transcatheter valves. Objective To examine the incidence, evolution, and effect on 1-year outcomes of PVR following TAVR with a third-generation balloon-expandable transcatheter heart valve. Design, Setting, and Participants Prespecified analysis of PVR in the Placement of Aortic Transcathete...
27 CitationsSource
#1Mohamed Jalloul Nsaibia (Laval University)H-Index: 6
#2Marie-Chloé Boulanger (Laval University)H-Index: 17
Last.Patrick Mathieu (Laval University)H-Index: 48
view all 14 authors...
Abstract Oxidatively modified lipoproteins may promote the development/progression of calcific aortic valve stenosis (CAVS). Oxidative transformation of low-density lipoprotein (OxLDL) generates lysophosphatidic acid (LPA), a lipid mediator that accumulates in mineralized aortic valves. LPA activates at least 6 different G protein-coupled receptors, which may play a role in the pathophysiology of CAVS. We hypothesized that LPA derived from OxLDL may promote a NF-κB signature that drives osteogen...
27 CitationsSource
#1Patrizio Lancellotti (University of Liège)H-Index: 78
#2Patricia A. Pellikka (Mayo Clinic)H-Index: 78
Last.Albert Varga (University of Szeged)H-Index: 29
view all 17 authors...
A unique and highly versatile technique, stress echocardiography (SE) is increasingly recognized for its utility in the evaluation of non-ischaemic heart disease. SE allows for simultaneous assessment of myocardial function and haemodynamics under physiological or pharmacological conditions. Due to its diagnostic and prognostic value, SE has become widely implemented to assess various conditions other than ischaemic heart disease. It has thus become essential to establish guidance for its applic...
82 CitationsSource
#1Lionel Tastet (Laval University)H-Index: 9
#2Romain Capoulade (Laval University)H-Index: 18
Last.Philippe Pibarot (Laval University)H-Index: 42
view all 14 authors...
Aims Hypertension is highly prevalent in patients with aortic stenosis (AS) and is associated with worse outcomes. The current prospective study assessed the impact of systolic hypertension (SHPT) on the progression of aortic valve calcification (AVC) measured by multidetector computed tomography (MDCT) in patients with AS. Methods and results The present analysis includes the first series of 101 patients with AS prospectively recruited in the PROGRESSA study. Patients underwent comprehensive Do...
18 CitationsSource
Prosthesis-patient mismatch (PPM) is present when the effective orifice area of the inserted prosthetic valve is too small in relation to body size. Its main hemodynamic consequence is to generate higher than expected gradients through normally functioning prosthetic valves. The purpose of this review is to present an update on the present state of knowledge with regards to diagnosis, prognosis and prevention of PPM. PPM is a frequent occurrence (20%–70% of aortic valve replacements) that has be...
4 Citations