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Anthony J. Demetris
University of Pittsburgh
613Publications
95H-index
39.7kCitations
Publications 611
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#1Annette M. Jackson (Duke University)H-Index: 22
#2Sai KanaparthiH-Index: 5
Last.Sandy Feng (UCSF: University of California, San Francisco)H-Index: 44
view all 7 authors...
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#2Andrew LesniakH-Index: 7
Last.Anthony J. DemetrisH-Index: 95
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#1Abraham Shaked (UPenn: University of Pennsylvania)H-Index: 56
#2Michele DesMaraisH-Index: 3
Last.Peter H. Sayre (UCSF: University of California, San Francisco)H-Index: 19
view all 13 authors...
1 CitationsSource
#1Sandy Feng (UCSF: University of California, San Francisco)H-Index: 44
#2John C. Bucuvalas (Cincinnati Children's Hospital Medical Center)H-Index: 35
Last.Alberto Sanchez-Fueyo ('KCL': King's College London)H-Index: 32
view all 26 authors...
Background & Aims A substantial proportion of pediatric liver transplant recipients develop subclinical chronic allograft injury. We studied whether there are distinct patterns of injury based on histopathologic features and identified associated immunologic profiles. Methods We conducted a cross-sectional study of 157 stable, long-term pediatric recipients of transplanted livers (70 boys; > 6 years old at time of transplantation; mean, 8.9 ± 3.46 years after liver transplantation) who underwent...
5 CitationsSource
#1Meike Welz (University of Bonn)H-Index: 4
#2Sarah Eickhoff (University of Bonn)H-Index: 4
Last.Wolfgang Kastenmüller (University of Würzburg)H-Index: 30
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CD8 T cells protect the liver against viral infection, but can also cause severe liver damage that may even lead to organ failure. Given the lack of mechanistic insights and specific treatment options in patients with acute fulminant hepatitis, we develop a mouse model reflecting a severe acute virus-induced CD8 T cell-mediated hepatitis. Here we show that antigen-specific CD8 T cells induce liver damage in a perforin-dependent manner, yet liver failure is not caused by effector responses target...
1 CitationsSource
#1Warren A. Zuckerman (CUMC: Columbia University Medical Center)H-Index: 10
#2Adriana Zeevi (University of Pittsburgh)H-Index: 63
Last.Steven A. Webber (Boston Children's Hospital)H-Index: 46
view all 22 authors...
6 CitationsSource
#1Anat R. Tambur (NU: Northwestern University)H-Index: 25
#2Patricia Campbell (U of A: University of Alberta)H-Index: 21
Last.Peter Nickerson (UM: University of Manitoba)H-Index: 45
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28 CitationsSource
#1Kathryn W Juchem (Yale University)H-Index: 2
#2Faruk Sacirbegovic (University of Pittsburgh)H-Index: 1
Last.Warren D. ShlomchikH-Index: 34
view all 9 authors...
Effector memory T cells (T EM ) are less capable of inducing graft-versus-host disease (GVHD) compared with naive T cells (T N ). Previously, in the TS1 TCR transgenic model of GVHD, wherein TS1 CD4 cells specific for a model minor histocompatibility Ag (miHA) induce GVHD in miHA-positive recipients, we found that cell-intrinsic properties of TS1 T EM reduced their GVHD potency relative to TS1 T N . Posttransplant, TS1 T EM progeny expressed higher levels of PD-1 than did TS1 T N progeny, leadin...
10 CitationsSource
OBJECTIVE. An American Association for the Study of Liver Diseases (AASLD) consensus document stressed the importance of obtaining sufficient liver biopsy specimens to minimize sampling errors. Man...
2 CitationsSource
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