Yu Hua
Tsinghua University
Nucleotide excision repairReplication protein ADNA repairSchizosaccharomyces pombeBiology
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Publications 3
#1Ling Guan (THU: Tsinghua University)H-Index: 1
#2Peng He (THU: Tsinghua University)H-Index: 1
Last. Daochun Kong (THU: Tsinghua University)H-Index: 13
view all 13 authors...
3 CitationsSource
#1Huimin Zhang (PKU: Peking University)H-Index: 1
#2Yu Hua (PKU: Peking University)H-Index: 3
Last. Daochun Kong (PKU: Peking University)H-Index: 13
view all 4 authors...
Abstract Double-stranded DNA breaks (DSBs) are highly detrimental DNA lesions, which may be repaired by the homologous recombination-mediated repair pathway. The 5 prime to 3 prime direction of long-range end resection on one DNA strand, in which 3 prime-single-strand DNA overhangs are created from broken DNA ends, is an essential step in this pathway. Dna2 has been demonstrated as an essential nuclease in this event, but the molecular mechanism how Dna2 is recruited to DNA break sites in vivo i...
4 CitationsSource
#1Jiazhi Hu (PKU: Peking University)H-Index: 12
#2Lei Sun (CAS: Chinese Academy of Sciences)H-Index: 3
Last. Daochun Kong (PKU: Peking University)H-Index: 13
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SUMMARY When replication forks stall at damaged bases or upon nucleotide depletion, the intra-S phase checkpoint ensures they are stabilized and can restart. In intra-S checkpoint-deficient budding yeast, stalling forks collapse, and � 10% form pathogenic chicken foot structures, contributing to incomplete replication and cell death (Lopes et al., 2001; Sogo et al., 2002; Tercero and Diffley, 2001). Using fission yeast, we report that the Cds1 Chk2 effector kinase targets Dna2 on S220 to regulat...
100 CitationsSource