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Christopher Leung
University of Melbourne
29Publications
7H-index
347Citations
Publications 29
Newest
#1Aowen Zhuang (UQ: University of Queensland)H-Index: 6
#2Felicia Y. T. Yap (Monash University)H-Index: 10
Last.Forbes Jm (UQ: University of Queensland)H-Index: 52
view all 10 authors...
The accumulation of advanced glycation end products (AGEs) have been implicated in the development and progression of diabetic kidney disease (DKD). There has been interest in investigating the potential of AGE clearance receptors, such as oligosaccharyltransferase-48 kDa subunit (OST48) to prevent the detrimental effects of excess AGE accumulation seen in the diabetic kidney. Here the objective of the study was to increase the expression of OST48 to examine if this slowed the development of DKD...
Source
#1Aowen Zhuang (UQ: University of Queensland)H-Index: 6
#2Felicia Y. T. Yap (Monash University)H-Index: 10
Last.Forbes Jm (UQ: University of Queensland)H-Index: 52
view all 12 authors...
The accumulation of advanced glycation end products (AGEs) have been implicated in the development and progression of diabetic kidney disease (DKD). There has been interest in investigating the potential of AGE clearance receptors, such as oligosaccharyltransferase-48kDa subunit (OST48) to prevent the detrimental effects of excess AGE accumulation seen in the diabetic kidney. Here the objective of the study was to increase the expression of OST48 to examine if this slowed the development of DKD ...
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#1Catherine Brock (University of Melbourne)
#2Yuan Yi (University of Melbourne)
Last.Christopher Leung (University of Melbourne)H-Index: 7
view all 7 authors...
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#1Eveline Bruinstroop (NUS: National University of Singapore)H-Index: 2
#2Rinkoo Dalan (TTSH: Tan Tock Seng Hospital)H-Index: 11
Last.Paul M. Yen (NUS: National University of Singapore)H-Index: 45
view all 22 authors...
7 CitationsSource
#1Christopher LeungH-Index: 7
#2Peter W AngusH-Index: 49
Last.Forbes JmH-Index: 52
view all 3 authors...
Hepatocellular carcinoma (HCC) is the second most common cause of cancer mortality worldwide and is the most rapidly growing indication for liver transplantation globally. There is, therefore, an urgent need to explore novel areas which may be contributing to pathogenesis such as advanced glycation pathways, to better understand HCC progression. Advanced glycation end-products (AGEs) are a group of biologically active compounds that are formed when sugar moieties react non-enzymatically with ami...
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#1Aowen Zhuang (UQ: University of Queensland)H-Index: 6
#2Felicia Y. T. Yap (Monash University, Clayton campus)H-Index: 10
Last.Forbes Jm (UQ: University of Queensland)H-Index: 52
view all 17 authors...
The protein oligosaccharyltransferase-48 (OST48) is integral to protein N-glycosylation in the endoplasmic reticulum (ER) but is also postulated to act as a membrane localised clearance receptor for advanced glycation end-products (AGE). Hepatic ER stress and AGE accumulation are each implicated in liver injury. Hence the objective of this study was to increase the expression of OST48 and examine the effects on hepatic function and structure. Groups of 8 week old male mice (n = 10–12/group) over...
7 CitationsSource
#1Simon R. Knowles (Swinburne University of Technology)H-Index: 16
#2David W. Austin (Deakin University)H-Index: 25
Last.Geoff Hebbard (University of Melbourne)H-Index: 11
view all 10 authors...
AbstractIrritable Bowel Syndrome (IBS) is a common condition affecting around 10–20% of the population and associated with poorer psychological well-being and quality of life. The aim of the current study was to explore the efficacy of the Common Sense Model (CSM) using Structural Equation Modelling (SEM) in an IBS cohort. One hundred and thirty-one IBS patients (29 males, 102 females, mean age 38 years) participating in the IBSclinic.org.au pre-intervention assessment were included. Measures in...
10 CitationsSource
This Review discusses the mechanisms via which changes in the gut can influence the development and progression of NAFLD. Understanding of such mechanisms is hoped to pave the way for new treatments for what has become the most common form of liver disease.
157 CitationsSource
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