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Christopher Leung
University of Melbourne
26Publications
7H-index
297Citations
Publications 26
Newest
Published on Jul 22, 2019in bioRxiv
Aowen Zhuang5
Estimated H-index: 5
,
Felicia Y.T. Yap10
Estimated H-index: 10
+ 9 AuthorsMelinda T. Coughlan30
Estimated H-index: 30
(Monash University)
The accumulation of advanced glycation end products (AGEs) have been implicated in the development and progression of diabetic kidney disease (DKD). There has been interest in investigating the potential of AGE clearance receptors, such as oligosaccharyltransferase-48kDa subunit (OST48) to prevent the detrimental effects of excess AGE accumulation seen in the diabetic kidney. Here the objective of the study was to increase the expression of OST48 to examine if this slowed the development of DKD ...
Published on Dec 1, 2018in Emergency Medicine Australasia 1.50
Catherine Brock (University of Melbourne), Yuan Yi (University of Melbourne)+ 4 AuthorsChristopher Leung7
Estimated H-index: 7
(University of Melbourne)
Published on Jul 1, 2018in The Journal of Clinical Endocrinology and Metabolism 5.61
Eveline Bruinstroop1
Estimated H-index: 1
(NUS: National University of Singapore),
Rinkoo Dalan10
Estimated H-index: 10
(TTSH: Tan Tock Seng Hospital)
+ 19 AuthorsMelvin Khee-Shing Leow17
Estimated H-index: 17
(Agency for Science, Technology and Research)
Published on Dec 1, 2017in Translational cancer research 1.07
Christopher Leung7
Estimated H-index: 7
,
Peter W Angus44
Estimated H-index: 44
,
Forbes Jm51
Estimated H-index: 51
Hepatocellular carcinoma (HCC) is the second most common cause of cancer mortality worldwide and is the most rapidly growing indication for liver transplantation globally. There is, therefore, an urgent need to explore novel areas which may be contributing to pathogenesis such as advanced glycation pathways, to better understand HCC progression. Advanced glycation end-products (AGEs) are a group of biologically active compounds that are formed when sugar moieties react non-enzymatically with ami...
Published on Dec 1, 2017in Scientific Reports 4.01
Aowen Zhuang5
Estimated H-index: 5
(UQ: University of Queensland),
Felicia Y.T. Yap10
Estimated H-index: 10
(Monash University, Clayton campus)
+ 14 AuthorsPhillip Kantharidis26
Estimated H-index: 26
(Baker IDI Heart and Diabetes Institute)
The protein oligosaccharyltransferase-48 (OST48) is integral to protein N-glycosylation in the endoplasmic reticulum (ER) but is also postulated to act as a membrane localised clearance receptor for advanced glycation end-products (AGE). Hepatic ER stress and AGE accumulation are each implicated in liver injury. Hence the objective of this study was to increase the expression of OST48 and examine the effects on hepatic function and structure. Groups of 8 week old male mice (n = 10–12/group) over...
Published on May 28, 2017in Psychology Health & Medicine 1.60
Simon R. Knowles15
Estimated H-index: 15
(Swinburne University of Technology),
David W. Austin23
Estimated H-index: 23
(Deakin University)
+ 7 AuthorsGeoff Hebbard11
Estimated H-index: 11
(University of Melbourne)
AbstractIrritable Bowel Syndrome (IBS) is a common condition affecting around 10–20% of the population and associated with poorer psychological well-being and quality of life. The aim of the current study was to explore the efficacy of the Common Sense Model (CSM) using Structural Equation Modelling (SEM) in an IBS cohort. One hundred and thirty-one IBS patients (29 males, 102 females, mean age 38 years) participating in the IBSclinic.org.au pre-intervention assessment were included. Measures in...
Published on Jul 1, 2016in Nature Reviews Gastroenterology & Hepatology 23.57
Christopher Leung7
Estimated H-index: 7
,
Leni R. Rivera14
Estimated H-index: 14
+ 1 AuthorsPeter W Angus44
Estimated H-index: 44
This Review discusses the mechanisms via which changes in the gut can influence the development and progression of NAFLD. Understanding of such mechanisms is hoped to pave the way for new treatments for what has become the most common form of liver disease.
Published on Jan 1, 2016in World Journal of Gastroenterology 3.41
Christopher Leung7
Estimated H-index: 7
,
Chandana B. Herath19
Estimated H-index: 19
+ 7 AuthorsPeter W Angus44
Estimated H-index: 44
AIM To determine if manipulation of dietary advanced glycation end product (AGE), intake affects nonalcoholic fatty liver disease (NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol (HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs....
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