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Tokiko Watanabe
University of Tokyo
24Publications
7H-index
296Citations
Publications 22
Newest
#1Tokiko Watanabe (UTokyo: University of Tokyo)H-Index: 7
#2Nobuhiro Suzuki (UTokyo: University of Tokyo)H-Index: 62
Last.Yoshihiro Kawaoka (UTokyo: University of Tokyo)H-Index: 120
view all 9 authors...
Abstract Given that approximately 1031 virus particles exist on Earth and all of them are parasitic in living organisms, it is not hard to imagine how virus infection might affect the physiology of hosts and their ecosystems. However, traditional virology research tends to focus on viral pathogenicity or the individual pathogenic viruses; hence, the significance of viruses and viral-mediated processes in the global ecosystem has been poorly understood. To identify the previously unrecognized “ra...
1 CitationsSource
#1Yahiro MukaiH-Index: 1
#2Yuriko Tomita (UTokyo: University of Tokyo)H-Index: 7
Last.Masayuki HorieH-Index: 17
view all 11 authors...
Viruses are believed to be ubiquitous; however, the diversity of viruses is largely unknown because of the bias of previous research toward pathogenic viruses. Deep sequencing is a promising and unbiased approach to detect viruses from animal-derived materials. Although cranes are known to be infected by several viruses such as influenza A viruses, previous studies targeted limited species of viruses, and thus viruses that infect cranes have not been extensively studied. In this study, we collec...
1 CitationsSource
#1Li Wu (UTokyo: University of Tokyo)
#2Hiromichi Mitake (UTokyo: University of Tokyo)H-Index: 1
Last.Yoshihiro Kawaoka (UTokyo: University of Tokyo)H-Index: 120
view all 14 authors...
Source
#1Huapeng Feng (UTokyo: University of Tokyo)H-Index: 1
#2Noriko Nakajima (NIH: National Institutes of Health)H-Index: 18
Last.Yoshihiro Kawaoka (UTokyo: University of Tokyo)H-Index: 120
view all 9 authors...
Vaccination is an effective strategy to control influenza disease. Adjuvants enhance the efficacy of vaccines, but few adjuvants are approved for human use, so novel, safe, and effective adjuvants are urgently needed. The glycolipid adjuvant 7DW8-5 has shown adjuvanticity to malaria vaccine; however, its adjuvant effect for seasonal influenza vaccine remains unknown. Here, we evaluated the adjuvanticity of 7DW8-5 to a quadrivalent split influenza vaccine in a mouse model. 7DW8-5 significantly en...
Source
#1Kosuke Takada (UTokyo: University of Tokyo)H-Index: 2
#2Chiharu KawakamiH-Index: 15
Last.Yoshihiro Kawaoka (UTokyo: University of Tokyo)H-Index: 120
view all 18 authors...
Here, we developed hCK, a Madin-Darby canine kidney (MDCK) cell line that expresses high levels of human influenza virus receptors and low levels of avian virus receptors. hCK cells supported human A/H3N2 influenza virus isolation and growth much more effectively than conventional MDCK or human virus receptor-overexpressing (AX4) cells. A/H3N2 viruses propagated in hCK cells also maintained higher genetic stability than those propagated in MDCK and AX4 cells.
2 CitationsSource
#1Peter Halfmann (UW: University of Wisconsin-Madison)H-Index: 22
#2Amie J. Eisfeld (UW: University of Wisconsin-Madison)H-Index: 20
Last.Foday SahrH-Index: 14
view all 12 authors...
The 2013–2016 Ebola virus outbreak in West Africa was the largest and deadliest outbreak to date. Here we conducted a serological study to examine the antibody levels in survivors and the seroconversion in close contacts who took care of Ebola-infected individuals, but did not develop symptoms of Ebola virus disease. In March 2017, we collected blood samples from 481 individuals in Makeni, Sierra Leone: 214 survivors and 267 close contacts. Using commercial, quantitative ELISAs, we tested the pl...
Source
#1Jennifer E. Kyle (PNNL: Pacific Northwest National Laboratory)H-Index: 11
#2Kristin E. Burnum-Johnson (PNNL: Pacific Northwest National Laboratory)H-Index: 14
Last.Thomas O. Metz (PNNL: Pacific Northwest National Laboratory)H-Index: 42
view all 11 authors...
Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural components, signaling molecules, and energy sources. Here we show that the plasma lipidomes of EVD survivors and fatalities from Sierra Leone, infected during the 2014–2016 Ebola virus outbreak, were pro...
Source
#1Huapeng Feng (UTokyo: University of Tokyo)H-Index: 1
#2Makoto Yamashita (UTokyo: University of Tokyo)H-Index: 7
Last.Yoshihiro Kawaoka (UTokyo: University of Tokyo)H-Index: 120
view all 5 authors...
Influenza outbreaks can be either seasonal or pandemic. Vaccination is an effective strategy to control influenza; however, the efficacy of the currently available inactivated influenza virus vaccines is suboptimal, especially in the elderly. Vaccine efficacy can be improved by the addition of adjuvants, but few adjuvants have been approved for human vaccines. To explore novel, safe, and effective adjuvants for influenza vaccines, here we used a mouse model to screen 46 injectable drug additives...
2 CitationsSource
#1Emily E. Ackerman (University of Pittsburgh)H-Index: 1
#2Eiryo Kawakami (UTokyo: University of Tokyo)H-Index: 18
Last.Yoshihiro KawaokaH-Index: 120
view all 11 authors...
ABSTRACT The positions of host factors required for viral replication within a human protein-protein interaction (PPI) network can be exploited to identify drug targets that are robust to drug-mediated selective pressure. Host factors can physically interact with viral proteins, be a component of virus-regulated pathways (where proteins do not interact with viral proteins), or be required for viral replication but unregulated by viruses. Here, we demonstrate a method of combining human PPI netwo...
1 CitationsSource
#1Tokiko Watanabe (UTokyo: University of Tokyo)H-Index: 7
#2Kiyoko Iwatsuki-Horimoto (UTokyo: University of Tokyo)H-Index: 23
Last.Yoshihiro Kawaoka (UTokyo: University of Tokyo)H-Index: 120
view all 10 authors...
Several animal models are used to study influenza viruses. Intranasal inoculation of animals with a liquid inoculum is one of the main methods used to experimentally infect animals with influenza virus; however, this method does not reflect the natural infection with influenza virus by contact or aerosol route. Aerosol inhalation methods have been established with several influenza viruses for mouse and ferret models, but few studies have evaluated inoculation routes in a nonhuman primates (NHP)...
4 CitationsSource
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