Kimberly M Lau
University of California, San Diego
Publications 1
#1Kimberly M Lau (UCSD: University of California, San Diego)
#2Ila M. Saunders (UM: University of Montana)H-Index: 3
Last.Aaron M. Goodman (UCSD: University of California, San Diego)H-Index: 9
view all 3 authors...
Pegaspargase, a long acting formulation of L-asparaginase, is an asparagine specific enzyme that selectively kills leukemic cells by depleting plasma asparagine. Pegaspargase is FDA approved for the first-line treatment of adult acute lymphoblastic leukemia and is a critical component of numerous multi-chemotherapeutic regimens. Pegaspargase is associated with well-described toxicities including hypersensitivity reactions, hepatotoxicity, and thrombosis. However, hypertriglyceridemia is a much r...