Samuli Ripatti
University of Helsinki
Publications 50
Cytokines are essential regulatory components of the immune system, and their aberrant levels have been linked to many disease states. Despite increasing evidence that cytokines operate in concert, many of the physiological interactions between cytokines, and the shared genetic architecture that underlies them, remain unknown. Here, we aimed to identify and characterize genetic variants with pleiotropic effects on cytokines. Using three population-based cohorts (n = 9,263), we performed multivar...
1 CitationsSource
#1Joel T. Rämö (UH: University of Helsinki)H-Index: 3
#2Pietari Ripatti (UH: University of Helsinki)H-Index: 2
Last.Samuli Ripatti (Broad Institute)H-Index: 23
view all 18 authors...
Background We asked whether, after excluding familial hypercholesterolemia, individuals with high low‐density lipoprotein cholesterol (LDL‐C) or triacylglyceride levels and a family history of the ...
1 CitationsSource
#1Pietari RipattiH-Index: 2
#2Joel T. RämöH-Index: 3
Last.Samuli RipattiH-Index: 23
view all 13 authors...
#1Pietari RipattiH-Index: 2
#2Joel T. RämöH-Index: 3
Last.Samuli RipattiH-Index: 23
view all 10 authors...
1 CitationsSource
#1Joel T. RämöH-Index: 3
#2Pietari RipattiH-Index: 2
Last.Samuli RipattiH-Index: 23
view all 15 authors...
1 CitationsSource
#1Himanshu Chheda (UH: University of Helsinki)H-Index: 7
#2Priit Palta (UT: University of Tartu)H-Index: 17
Last.Samuli Ripatti (UH: University of Helsinki)H-Index: 23
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Whole-genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom
24 CitationsSource
#1Gad Abraham (University of Melbourne)H-Index: 14
#2Aki S. Havulinna (National Institute for Health and Welfare)H-Index: 44
Last.Michael Inouye (University of Melbourne)H-Index: 43
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Aims Genetics plays an important role in coronary heart disease (CHD) but the clinical utility of genomic risk scores (GRSs) relative to clinical risk scores, such as the Framingham Risk Score (FRS), is unclear. Our aim was to construct and externally validate a CHD GRS, in terms of lifetime CHD risk and relative to traditional clinical risk scores. Methods and results We generated a GRS of 49 310 SNPs based on a CARDIoGRAMplusC4D Consortium meta-analysis of CHD, then independently tested it usi...
92 CitationsSource
#1Emmi Tikkanen (UH: University of Helsinki)H-Index: 27
#2Matti Pirinen (UH: University of Helsinki)H-Index: 31
Last.Samuli Ripatti (UH: University of Helsinki)H-Index: 23
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Aims/hypothesis Epidemiological studies have identified several traits associated with CHD, but few of these have been shown to be causal risk factors and thus suitable targets for treatment. Our aim was to evaluate the causal role of a large set of known CHD risk factors using single-nucleotide polymorphisms (SNPs) as instrumental variables.
5 CitationsSource
#1Susanna Lemmelä (Finnish Institute of Occupational Health)H-Index: 8
#2Svetlana Solovieva (Finnish Institute of Occupational Health)H-Index: 31
Last.Kirsti Husgafvel-Pursiainen (Finnish Institute of Occupational Health)H-Index: 42
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Sciatica or the sciatic syndrome is a common and often disabling low back disorder in the working-age population. It has a relatively high heritability but poorly understood molecular mechanisms. The Finnish population is a genetic isolate where small founder population and bottleneck events have led to enrichment of certain rare and low frequency variants. We performed here the first genome-wide association (GWAS) and meta-analysis of sciatica. The meta-analysis was conducted across two GWAS co...
4 CitationsSource
#1Giulia Orlando (ICR: Institute of Cancer Research)H-Index: 7
#2Philip J. Law (ICR: Institute of Cancer Research)H-Index: 12
Last.Richard S. Houlston (ICR: Institute of Cancer Research)H-Index: 93
view all 57 authors...
To identify new risk loci for colorectal cancer (CRC), we conducted a meta-analysis of seven genome-wide association studies (GWAS) with independent replication, totalling 13 656 CRC cases and 21 667 controls of European ancestry. The combined analysis identified a new risk association for CRC at 2q35 marked by rs992157 (P = 3.15 × 10−8, odds ratio = 1.10, 95% confidence interval = 1.06–1.13), which is intronic to PNKD (paroxysmal non-kinesigenic dyskinesia) and TMBIM1 (transmembrane BAX inhibit...
20 CitationsSource