Brian H. Annex
University of Virginia
Publications 34
#1Daniel L Hess (UVA: University of Virginia)H-Index: 3
#2Molly R. Kelly-Goss (UVA: University of Virginia)H-Index: 5
Last.Gary K. Owens (UVA: University of Virginia)H-Index: 73
view all 9 authors...
The stem cell pluripotency factor Oct4 serves a critical protective role during atherosclerotic plaque development by promoting smooth muscle cell (SMC) investment. Here, we show using Myh11-CreERT2 lineage-tracing with inducible SMC and pericyte (SMC-P) knockout of Oct4 that Oct4 regulates perivascular cell migration and recruitment during angiogenesis. Knockout of Oct4 in perivascular cells significantly impairs perivascular cell migration, increases perivascular cell death, delays endothelial...
1 CitationsSource
#1Brian P. Davidson (OHSU: Oregon Health & Science University)H-Index: 12
#2James Hodovan (OHSU: Oregon Health & Science University)H-Index: 1
Last.Jonathan R. Lindner (Oregon National Primate Research Center)H-Index: 69
view all 9 authors...
Background In patients with peripheral artery disease (PAD), the severity of symptoms correlates poorly with ankle-brachial index (ABI). The aim of this study was to test the hypothesis that limb perfusion assessed using contrast-enhanced ultrasound (CEU) during contractile exercise varies according to functional class in patients with PAD, particularly those with ABIs in the 0.4 to 0.6 range whose symptoms vary widely. Methods Bilateral quantitative CEU perfusion imaging of the calf was perform...
#1Nabil E. Boutagy (Yale University)H-Index: 5
#2Silvia Ravera (Yale University)H-Index: 4
Last.Albert J. Sinusas (Yale University)H-Index: 46
view all 12 authors...
Background: We propose micro single-photon emission computed tomography/computed tomography imaging of the hNIS (human sodium/iodide symporter) to noninvasively quantify adeno-associated virus 9 (A...
#1Samson Okello (Harvard University)H-Index: 9
#2Fardous Charles Abeya (Mbarara University of Science and Technology)H-Index: 1
Last.Andrew J. Buda (University of Virginia Health System)H-Index: 2
view all 7 authors...
Background The health-related quality of life (HRQoL) is an important treatment goal that could serve as low-cost prognostication tool in resource poor settings. We sought to validate the Kansas City Cardiomyopathy Questionnaire (KCCQ) and evaluate its use as a predictor of 3 months all-cause mortality among heart failure participants in rural Uganda.
#1Terence E. RyanH-Index: 18
#2Dean J. YamaguchiH-Index: 2
Last.J M. McClungH-Index: 22
view all 16 authors...
6 CitationsSource
#1Fardous Charles Abeya (Mbarara University of Science and Technology)H-Index: 1
#2Boniface Amanee Elias Lumori (Mbarara University of Science and Technology)H-Index: 1
Last.Samson Okello (Harvard University)H-Index: 9
view all 6 authors...
Abstract Objective We sought to estimate the incidence and predictors of all-cause mortality 6 months after heart failure hospitalization in Uganda. Methods Mbarara Heart Failure Registry is a cohort of patients hospitalized with a clinical diagnosis of heart failure at Mbarara Regional Referral Hospital, Uganda. We measured serum electrolytes, cardiac markers, and echocardiograms. All participants were followed until death or end of 6 months. We used Fine and Gray models to estimate the inciden...
4 CitationsSource
#1Brian H. Annex (University of Virginia Health System)H-Index: 14
Peripheral Arterial Disease (PAD) is one of the major complications of systemic atherosclerosis where occlusions along the major arterial pathway that supplies blood to the lower extremities is interrupted and blood flow to the distal limb becomes dependent on the presence, extent, and function of collateral blood vessels. Estimates are PAD is present in ~8.5 million Americans at or over the age of 40 and the two major clinical manifestations of PAD are intermittent claudication (IC) and critica...
#1Parviz K. Kavoussi (Department of Urology, University of Virginia)H-Index: 7
#2K. Heberlein (University of Virginia Health System)H-Index: 1
Last.Jeffrey J. Lysiak (Department of Urology, University of Virginia)H-Index: 22
view all 10 authors...
Summary Myoendothelial junctions are specialised projections of cell : cell contact through the internal elastic lamina between endothelial cells and vascular smooth muscle cells. These junctions allow for endothelial cells and vascular smooth muscle cells to make direct membrane apposition and are involved in cell : cell communication. In this study, we evaluated for the presence of myoendothelial junctions in murine corporal tissue and used plasminogen activator inhibitor (PAI)-1-deficient mic...
1 CitationsSource
#1Samson OkelloH-Index: 9
#2Michael KanyesigyeH-Index: 5
Last.Mark J. SiednerH-Index: 25
view all 7 authors...
The successful scale-up of antiretroviral therapy (ART) in sub-Saharan Africa substantially reduced mortality from AIDS-related between 2001 and 2012.[1] The increase in access to ART has led to reductions in opportunistic-infection related mortality for people living with HIV (PLWH), and increasing life expectancy, which has approached that of HIV-uninfected persons in the region.[2-5] As a result, it is projected that the number of adults living with HIV in sub-Saharan Africa over the age of 6...
20 CitationsSource