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Qin Wang
Harbin Medical University
Downregulation and upregulationCancer researchBreast cancerCarcinogenesisBiology
7Publications
3H-index
36Citations
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Publications 7
Newest
#1Lei Liu (HMU: Harbin Medical University)
#2Qin Wang (HMU: Harbin Medical University)H-Index: 3
Last. Shouping Xu (HMU: Harbin Medical University)H-Index: 6
view all 9 authors...
Immunotherapy, designed to exploit the functions of the host immune system against tumors, has shown considerable potential against several malignancies. However, the utility of immunotherapy is heavily limited due to the low response rate and various side effects in the clinical setting. Immune escape of tumor cells may be a critical reason for such low response rates. Noncoding RNAs (ncRNAs) have been identified as key regulatory factors in tumors and the immune system. Consequently, ncRNAs sh...
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#1Shouping Xu (HMU: Harbin Medical University)H-Index: 6
#2Qin Wang (HMU: Harbin Medical University)H-Index: 3
Last. Meiying Shen (HMU: Harbin Medical University)H-Index: 1
view all 12 authors...
Long noncoding RNAs (lncRNAs) that are associated with immune checkpoints have not been identified, and the mechanism by which such lncRNAs might regulate the expression of immune checkpoints is unknown in human cancer. Immune checkpoint-associated long noncoding RNAs (ICP-lncRNAs) were identified and validated via a comprehensive bioinformatic analysis of The Cancer Genome Atlas (TCGA) data. These ICP-lncRNAs were involved in key immune response and immune cell receptor signaling pathways. The ...
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#1Shouping Xu (HMU: Harbin Medical University)H-Index: 6
#1Shouping Xu (HMU: Harbin Medical University)H-Index: 1
Last. Da Pang (HMU: Harbin Medical University)H-Index: 1
view all 9 authors...
The landscape of molecular subtype-specific long intergenic noncoding RNAs (MS-lincRNAs) in breast cancer has not been elucidated. No study has investigated the biological function of BCLIN25, serving as a novel HER2 subtype-specific lincRNA, in human disease, especially in malignancy. Moreover, the mechanism of BCLIN25 in the regulation of ERBB2 expression remains unknown. Our present study aimed to investigate the role and underlying mechanism of BCLIN25 in the regulation of ERBB2 expression. ...
1 CitationsSource
#1Kun Qiao (HMU: Harbin Medical University)H-Index: 2
#2Shipeng Ning (HMU: Harbin Medical University)H-Index: 3
Last. Da Pang (HMU: Harbin Medical University)H-Index: 21
view all 8 authors...
An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play essential roles in tumor initiation and progression. LncRNAs act as tumor promoters or suppressors by targeting specific genes via epigenetic modifications and competing endogenous RNA (ceRNA) mechanisms. In this study, we explored the function and detailed mechanisms of long intergenic nonprotein coding RNA 673 (LINC00673) in breast cancer progression. Quantitative real-time PCR (qRT-PCR) was used to examine the ...
6 CitationsSource
#1Boran Pang (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Shiyao Sui (HMU: Harbin Medical University)H-Index: 5
Last. Shouping Xu (HMU: Harbin Medical University)H-Index: 6
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: The function of DLEU1 in human cancer is largely unknown. The Cancer Genome Atlas data were applied to identify the landscape of differential genes between tumor tissues and normal tissues, which was further validated by our cohort data and pan-cancer data including 33 cancer types with 11,060 patients. Next, DLEU1 was selected to validate the novel finding and result showed that it promoted tumorigenesis in vitro and in vivo. Mechanistically, DLEU1 promotes SRP4 expression via increasing H3K2...
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#1Shouping Xu (HMU: Harbin Medical University)H-Index: 6
#2Peiyuan Wang (HMU: Harbin Medical University)H-Index: 5
Last. Da Pang (HMU: Harbin Medical University)H-Index: 21
view all 11 authors...
Background The biology function of antisense intronic long noncoding RNA (Ai-lncRNA) is still unknown. Meanwhile, cancer patients with paclitaxel resistance have limited therapeutic options in the clinic. However, the potential involvement of Ai-lncRNA in paclitaxel sensitivity remains unclear in human cancer.
3 CitationsSource
#1Shiyao Sui (HMU: Harbin Medical University)H-Index: 5
#2Jian Zhang (HMU: Harbin Medical University)H-Index: 5
Last. Da Pang (HMU: Harbin Medical University)H-Index: 21
view all 6 authors...
(+)-JQ1 is an inhibitor of the tumor-driver bromodomain protein BRD4 and produces satisfactory effects because it efficiently increases apoptosis. Ferroptosis is an oxidative cell death program differing from apoptosis. Ferroptosis is characterized by high levels of iron and reactive oxygen species and has been confirmed to suppress tumor growth. In this study, BRD4 expression in cancer and its influence on the prognosis of cancer patients were analyzed using data from public databases. In addit...
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