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Lingjun Chen
Zhejiang University
Oxidative stressDMT1FerritinBiochemistryIntracellular
3Publications
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Publications 3
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#1Lingjun Chen (ZJU: Zhejiang University)H-Index: 1
#2Xiaonan Yu (ZJU: Zhejiang University)H-Index: 2
Last. Jie Feng (ZJU: Zhejiang University)H-Index: 11
view all 6 authors...
The current study aimed to investigate the influence of four supplemental zinc salts (chelated: Zn glycine; non-chelated: Zn sulfate, Zn citrate, Zn gluconate) among different zinc concentrations (30–300 μM) on cell proliferation, oxidative stress, and energy depletion in intestinal porcine jejunum epithelial cells (IPEC-J2). Different zinc salts affected cell viability in a time- and dose-dependent manner, which was mainly dependent on the uptake of intracellular Zn2+. Intracellular Zn2+ of Zn ...
1 CitationsSource
#1Haoxuan Ding (ZJU: Zhejiang University)H-Index: 2
#2Xiaonan Yu (ZJU: Zhejiang University)H-Index: 2
Last. Jie Feng (ZJU: Zhejiang University)H-Index: 11
view all 6 authors...
Iron supplementation has been an intervention to improve iron storage and prevent iron deficiency anemia in weaned piglets and has set recommended nutrient intake (RNI) and tolerable upper intake levels (UL). The purpose of this study was to investigate the potential harm of UL iron to the gut and microbes of weaned piglets. Thirty 23-day old weaned piglets were assigned to three dietary treatments: a basal diet supplemented with 100 (RNI), 300, or 3000 (UL) mg FeSO4/kg diet for 28 days. Then, w...
Source
#1Xiaonan Yu (ZJU: Zhejiang University)H-Index: 2
#2Lingjun Chen (ZJU: Zhejiang University)H-Index: 1
Last. Jie Feng (ZJU: Zhejiang University)H-Index: 11
view all 5 authors...
This experiment was conducted to investigate the transport characteristics of iron from ferrous bisglycinate (Fe-Gly) in intestinal cells. The divalent metal transporter 1 (DMT1)-knockout Caco-2 cell line was developed by Crispr-Cas9, and then the cells were treated with ferrous sulfate (FeSO4) or Fe-Gly to observe the labile iron pool and determine their iron transport. The results showed that the intracellular labile iron increased significantly with Fe-Gly or FeSO4 treatment, and this phenome...
2 CitationsSource
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