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Giordano Reginato
ETH Zurich
2Publications
1H-index
34Citations
Publications 2
Newest
#1Elda Cannavo (USI: University of Lugano)H-Index: 13
#2Giordano Reginato (ETH Zurich)H-Index: 1
Last.Petr Cejka (ETH Zurich)H-Index: 28
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To repair DNA double-strand breaks by homologous recombination, the 5′-terminated DNA strands must first be resected to produce 3′ overhangs. Mre11 from Saccharomyces cerevisiae is a 3′ → 5′ exonuclease that is responsible for 5′ end degradation in vivo. Using plasmid-length DNA substrates and purified recombinant proteins, we show that the combined exonuclease and endonuclease activities of recombinant MRX-Sae2 preferentially degrade the 5′-terminated DNA strand, which extends beyond the vicini...
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#1Giordano Reginato (ETH Zurich)H-Index: 1
#2Elda Cannavo (USI: University of Lugano)H-Index: 13
Last.Petr Cejka (ETH Zurich)H-Index: 28
view all 3 authors...
34 CitationsSource
1