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Momoko Suzuki
Meiji Pharmaceutical University
2Publications
Publications 2
Newest
#1Momoko Suzuki (Meiji Pharmaceutical University)
#2Shougo Hashimoto (Meiji Pharmaceutical University)
Last.Kenichi Kobayashi (Meiji Pharmaceutical University)H-Index: 4
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Epothilone D, a microtubule-stabilizing macrolide, is an attractive synthetic target molecule as a potential anti-cancer drug candidate. As part of our ongoing synthetic studies of this natural pro...
#1Kosaku Tanaka (Meiji Pharmaceutical University)H-Index: 2
#2Yusuke Honma (Meiji Pharmaceutical University)
Last.Kenichi Kobayashi (Meiji Pharmaceutical University)H-Index: 4
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Abstract The relative and absolute configurations of L-755,807 were established through total synthesis. All four possible stereoisomers were prepared via a convergent synthetic strategy, including a novel diastereoselective Darzens reaction of an α-alkoxy aldehyde with di- tert -butyl bromomalonate, an E -selective Horner–Wadsworth–Emmons reaction, and late-stage coupling of the ring and side-chain segments. Additionally, biological evaluation of the synthesized compounds revealed their potent ...
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