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Lei Zhao
Hebei University
GeneMolecular biologyCancer researchLong non-coding RNABiology
3Publications
2H-index
9Citations
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Publications 4
Newest
#1Lili Lan (Hebei Medical University)
#2Huan Cao (Hebei Medical University)H-Index: 2
Last. Baoshan Wang (Hebei Medical University)H-Index: 4
view all 7 authors...
Abstract Background Long noncoding RNAs (lncRNAs) play crucial role in formation and progression of tumors. DNA methylation has become increasingly recognized as a frequent event of epigenetic alterations and one of the primary mechanisms of gene inactivation. The research aims to investigate the biofunction of a novel lncRNA in LSCC. Methods qRT-PCR, BGS, and MSP methods were employed to measure the relative expression level and methylation status of LINC00886. Additionally, we examined the eff...
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#1Weina Cui (Hebei Medical University)H-Index: 2
#2Wenxia Meng (Hebei Medical University)H-Index: 2
Last. Baoshan Wang (Hebei Medical University)H-Index: 4
view all 6 authors...
2 CitationsSource
#1Lei Zhao (Hebei University)H-Index: 2
#2Huan Cao (Hebei Medical University)H-Index: 2
Last. Baoshan Wang (Hebei Medical University)H-Index: 4
view all 7 authors...
Abstract In order to explore the differentially expressed long non-coding RNAs (lncRNAs) in laryngeal squamous cell carcinoma (LSCC), the GSE84957 lncRNA expression profile was included in the present study through data mining in the National Center for Biotechnology Information/Gene Expression Omnibus (NCBI/GEO). Then, the differentially expressed genes (DEGs) of LSCC (1646 lncRNAs and 2713 mRNAs, fold change ≥ 2, P ≤ 0.05) were identified from the GSE84957 dataset using bioinformatics analysis...
2 CitationsSource
#1Wenxia Meng (Hebei Medical University)H-Index: 2
#2Weina Cui (Hebei Medical University)H-Index: 2
Last. Baoshan Wang (Hebei Medical University)H-Index: 4
view all 6 authors...
Background Dysregulated long noncoding RNAs (lncRNAs) are involved in the development of tumor. Aberrant methylation is one of the most frequent epigenetic alterations that regulate the expression of genes. The aim of this study was to determine the expression and methylation status of ZNF667-AS1 and ZNF667, elucidate their biological function in the development of LSCC, and identify a cis-regulation of ZNF667-AS1 to ZNF667.
5 CitationsSource
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