Yeong Gi Kim
EndocrinologySerotoninTPH1Serotonin ProductionBiology
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Publications 4
#1Joon Ho Moon (KAIST)H-Index: 1
#2Yeong Gi Kim (KAIST)H-Index: 2
Last. Hail Kim (KAIST)H-Index: 20
view all 18 authors...
A sufficient β-cell mass is crucial for preventing diabetes, and perinatal β-cell proliferation is important in determining the adult β-cell mass. However, it is not yet known how perinatal β-cell proliferation is regulated. Here, we report that serotonin regulates β-cell proliferation through serotonin receptor 2B (HTR2B) in an autocrine/paracrine manner during the perinatal period. In β-cell–specific Tph1 knockout (Tph1 βKO) mice, perinatal β-cell proliferation was reduced along with the loss ...
#1Hyeongseok Kim (KAIST)H-Index: 8
#2Yeong Gi Kim (KAIST)H-Index: 2
Last. Hail Kim (KAIST)H-Index: 20
view all 10 authors...
Recent studies on tissue-autonomous serotonin (5-hydroxytryptamine [5-HT]) function have identified new roles for 5-HT in peripheral organs. Most of these studies were performed by crossing mice carrying the Tph1tm1Kry allele with tissue specific Cre mice. In the present study, we found that 5-HT production was not completely abolished in Tph1tm1Kry KO mice. The residual 5-HT production in Tph1tm1Kry KO mice is attributed to the expression of a truncated form of TPH1 containing the catalytic dom...
1 CitationsSource
#1Yeong Gi Kim (KAIST)H-Index: 2
#2Joon Ho Moon (KAIST)H-Index: 1
Last. Hail Kim (KAIST)H-Index: 20
view all 10 authors...
Abstract Serotonin is known to be present in pancreatic β-cells and to play several physiological roles, including insulin secretion, β-cell proliferation, and paracrine inhibition of α-cells. However, the serotonin production of different cell lines and islets has not been compared based on age, sex, and diabetes related conditions. Here, we directly compared the serotonin concentrations in βTC and MIN6 cell lines, as well as in islets from mice using ultra-performance liquid chromatography tan...
2 CitationsSource
#1Hitoshi IidaH-Index: 3
#2Takeshi OgiharaH-Index: 22
Last. Hirotaka WatadaH-Index: 52
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Serotonin signaling plays key roles in augmentation of pancreatic b-cell function during pregnancy. Increased expression of tryptophan hydroxylase 1 (Tph1), a rate-limiting enzyme for serotonin synthesis by lactogenic hormones, is involved in this phenomenon. To investigate its mechanisms, we here performed 5 0 -RACE and identified b-cell-specific
10 CitationsSource