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Samreen Sadaf
Central Drug Research Institute
Mitochondrial ROSNADPH oxidaseNeutrophil differentiationBiochemistryBiology
4Publications
1H-index
3Citations
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Publications 5
Newest
#1Samreen Sadaf (Central Drug Research Institute)H-Index: 1
#2Deepika Awasthi (Central Drug Research Institute)H-Index: 7
Last. Madhu Dikshit (Central Drug Research Institute)H-Index: 34
view all 7 authors...
Abstract Previous studies from this lab and others have demonstrated that nitric oxide (NO) in a concentration dependent manner, modulated neutrophil and leukemic cell survival. Subsequent studies delineated importance of iNOS in neutrophil differentiation and leukemic cell death. On the contrary, role of nNOS in survival of these cells remains least understood. Present study was therefore undertaken to assess and compare the role of iNOS and nNOS in the survival of NOS overexpressing myelocytic...
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#1Deepika Awasthi (Central Drug Research Institute)H-Index: 7
#2Sheela Nagarkoti (Central Drug Research Institute)H-Index: 5
Last. Madhu Dikshit (Central Drug Research Institute)H-Index: 34
view all 6 authors...
Abstract Neutrophil extracellular traps (NETs) play a pivotal role in the innate immune defense, as well as in the pathophysiology of various inflammatory disease conditions. Two major types of NETosis have been described - NOX-dependent and independent. The present study was undertaken to assess metabolic requirements of NETs formation by using PMA and A23187 as the inducers of NOX-dependent and NOX-independent NETosis respectively. Both these inducers caused an increase in ECAR, lactate dehydr...
1 CitationsSource
#1Sheela Nagarkoti (Central Drug Research Institute)H-Index: 5
#2Megha Dubey (Central Drug Research Institute)H-Index: 8
Last. Madhu Dikshit (Translational Health Science and Technology Institute)H-Index: 1
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Neutrophil survival and oxidative stress during inflammatory conditions are linked to tissue damage. The present study explores less understood role of catalase, the enzyme catalysing hydrogen peroxide decomposition, in neutrophil survival/death. Importantly, inhibition of catalase activity following S-glutathionylation in the PMA, NO, or zymosan-activated neutrophils or treatment with catalase inhibitor led to neutrophil death. On the contrary, introducing reducing environment by TCEP rescued c...
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#1Samreen Sadaf (Central Drug Research Institute)H-Index: 1
#2Abhishek Singh (Central Drug Research Institute)H-Index: 11
Last. Madhu Dikshit (Central Drug Research Institute)H-Index: 34
view all 10 authors...
1 CitationsSource
#1Sheela Nagarkoti (Central Drug Research Institute)H-Index: 5
#2Samreen Sadaf (Central Drug Research Institute)H-Index: 1
Last. Madhu DikshitH-Index: 34
view all 7 authors...
Recent report from this lab has shown role of Rac2 in the translocation of inducible nitric oxide synthase (iNOS) to the phagosomal compartment of polymorphonuclear leukocytes (PMNs) following phagocytosis of beads. This study was undertaken to further assess the status and role of tetrahydrobiopterin (BH4), a redox-sensitive cofactor, L-arginine, and the substrate of nitric oxide synthase (NOS) in sustained nitric oxide (˙NO) production in killing of phagocytosed microbes (Escherichia coli) by ...
1 CitationsSource
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