Orly Eshach-Adiv
Boston Children's Hospital
EndocrinologyLamivudineDiabetes mellitusMedicineGastroenterology
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Publications 13
#1Alina KurolapH-Index: 6
#2Orly Eshach-AdivH-Index: 9
Last. Hagit N. BarisH-Index: 16
view all 14 authors...
Background Intestinal integrity is essential for proper nutrient absorption and tissue homeostasis, with damage leading to enteric protein loss, that is, protein-losing enteropathy (PLE). Recently, homozygous nonsense variants in the plasmalemma vesicle-associated protein gene ( PLVAP ) were reported in two patients with severe congenital PLE. PLVAP is the building block of endothelial cell (EC) fenestral diaphragms; its importance in barrier function is supported by mouse models of Plvap defici...
4 CitationsSource
Objectives: Upper endoscopy (esophagogastroduodenoscopy [EGD]) has a limited role, if any, in the evaluation of functional abdominal pain (FAP). Nevertheless, children with intractable FAP are occasionally referred to EGD to rule out intestinal pathology. We evaluated the role of wireless video capsule endoscopy (VCE) in children referred for EGD with a diagnosis of FAP. Patients and Methods: Ten children older than 10 years of age were prospectively enrolled. Children were first studied with th...
31 CitationsSource
Objectives: Prolonged lamivudine treatment in adults has been shown to improve hepatitis B e (HBe) seroconversion rates in patients with chronic hepatitis B. This prospective open study reports the results of prolonged lamivudine treatment in a group of children with chronic hepatitis B. Patients and Methods: Twenty-two children and adolescents age 13.2 years (range, 9.5-18 years), who have been treated with lamivudine for 1 year, continued treatment with lamivudine (3 mg/kg/day, up to 100 mg/d)...
17 CitationsSource
#1Lea Bentur (Boston Children's Hospital)H-Index: 29
#2Bayan Hino (Technion – Israel Institute of Technology)H-Index: 2
Last. Drora Berkowitz (Technion – Israel Institute of Technology)H-Index: 3
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Abstract Background Cystic fibrosis (CF) is frequently associated with gastrointestinal complaints that can be due to gastrointestinal dysmotility. Electrogastrography (EGG) is an attractive, non-invasive procedure to assess gastric electric activity. The aims of our study were to investigate EGG abnormalities in pancreatic sufficient and pancreatic insufficient CF patients, and to examine whether EGG correlates with gastric emptying as assessed by scintigraphy. Methods EGG was performed in 23 C...
14 CitationsSource
ABSTRACTObjectives:Osteoporosis is the most common manifestation of untreated celiac disease (CD). Bone quantitative ultrasound (QUS) has recently emerged as a new modality for bone status assessment. We evaluated bone status in children with CD using dual-energy x-ray absorptiometry and quantitativ
52 CitationsSource
Background: There are few reports which the tests used for diagnosing Helicobacter pylori infection and monitoring its eradication in children. Study Aims: Prospective evaluation of invasive (gastric histology, rapid urease test [RUT]) and non-invasive (stool antigen [FemtoLab H. pylori], urea breath test [UBT]) tests in the diagnosis of H. pylori infection and post-treatment eradication in children and adolescents. Methods: Ninety-two patients (50 male, 42 female) referred for upper gastrointes...
49 CitationsSource
1 CitationsSource
#1Corina HartmanH-Index: 18
#2Raanan ShamirH-Index: 50
Last. Riva BrikH-Index: 26
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OBJECTIVE: To evaluate the validity of quantitative ultrasound bone sonometry (QUBS) as a screening tool for the diagnosis of osteoporosis in children with chronic rheumatic diseases (CRD), compared to the conventional dual energy x-ray absorptiometry (DEXA). METHODS: Forty children with CRD [32 with juvenile idiopathic arthritis (JIA), 6 with systemic lupus erythematosus, and 2 with dermatomyositis] aged 9.9 +/- 4.3 years, were evaluated by QUBS of radius and tibia and DEXA of the lumbar spine....
44 Citations
Objectives Only a few reports of nonsyndromic paucity of interlobular bile ducts (NS-PILBD) have been published. The authors' aim was to outline the clinical and laboratory profile of patients with NS-PILBD diagnosed at a tertiary referral center. Methods The authors reviewed all the reports of pediatric liver biopsies performed between 1991 and 2000 at their institution. Upon diagnosis of NS-PILBD, patients' records were examined for clinical, laboratory, and histologic data, and liver biopsy s...
16 CitationsSource
#1Alexander Dzakovic (Boston Children's Hospital)H-Index: 8
#2Amir Kaviani (Boston Children's Hospital)H-Index: 7
Last. Tom Jaksic (Boston Children's Hospital)H-Index: 44
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Abstract Background During total parenteral nutrition (TPN), hepatic concentration of the important intracellular antioxidant glutathione (GSH) is decreased. This study sought to determine whether enteral trophic (small quantity) feeding of GSH precursors would increase hepatic GSH levels during TPN and result in decreased peroxidative injury after endotoxin exposure. Methods Sprague-Dawley rats received full TPN for 7 days with postpyloric infusions of either (1) amino acid GSH precursors (cyst...
10 CitationsSource