Caroline F. Ribeiro
Harvard University
Publications 4
Last.Massimo LodaH-Index: 1
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#1Hubert Pakula (Harvard University)H-Index: 3
#2Caroline F. Ribeiro (Harvard University)H-Index: 1
Last.Massimo Loda (Harvard University)H-Index: 101
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The control region of TMPRSS2 fuses with ETS transcription factor family members, particularly ERG. This occurs in ~20-50% of human prostate cancers depending on the ethnicity. TMPRSS2-ERG (T2E) fusions, however, do not display a notable phenotype in genetically engineered mouse models (GEMM) recapitulating the fusion expression and T2E also has no prognostic significance in humans, despite its high incidence. Wnt signaling has been implicated in prostate cancer. Here, we report a discovery of a...
#1Giorgia Zadra (Harvard University)H-Index: 16
#2Caroline F. Ribeiro (Harvard University)H-Index: 1
Last.Massimo Loda (Broad Institute)H-Index: 101
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A hallmark of prostate cancer progression is dysregulation of lipid metabolism via overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis. Metastatic castration-resistant prostate cancer (mCRPC) develops resistance to inhibitors of androgen receptor (AR) signaling through a variety of mechanisms, including the emergence of the constitutively active AR variant V7 (AR-V7). Here, we developed an FASN inhibitor (IPI-9119) and demonstrated that selective FASN inhib...
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