J. K. Joung
Harvard University
Publications 2
#1M. Ma (VT: Virginia Tech)H-Index: 1
#2A. A. Ramirez (Cornell University)H-Index: 1
Last.Yu Pan (VT: Virginia Tech)H-Index: 1
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Down Syndrome Cell Adhesion Molecules (dscam and dscaml1) are essential regulators of neural circuit assembly, but their roles in vertebrate neural circuit function are still mostly unexplored. We investigated the role of dscaml1 in the zebrafish oculomotor system, where behavior, circuit function, and neuronal activity can be precisely quantified. Loss of zebrafish dscaml1 resulted in deficits in retinal patterning and light adaptation, consistent with its known roles in mammals. Oculomotor ana...
#1Steven J. Grzegorski (UM: University of Michigan)H-Index: 4
#2Zhilian Hu (UM: University of Michigan)H-Index: 2
Last.Jordan A. Shavit (UM: University of Michigan)H-Index: 13
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The ability to prevent blood loss in response to injury is a critical, evolutionarily conserved function of all vertebrates. Prothrombin (F2) contributes to both primary and secondary hemostasis through the activation of platelets and the conversion of soluble fibrinogen to insoluble fibrin, respectively. Complete prothrombin deficiency has never been observed in humans and is incompatible with life in mice, limiting the ability to understand the entirety of prothrombins in vivo functions. We ha...