Yuhan Shi
Chinese Academy of Sciences
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Publications 2
#1Sanlan Li (CAS: Chinese Academy of Sciences)H-Index: 2
#2Yuhan Shi (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Leping Cheng (CAS: Chinese Academy of Sciences)H-Index: 18
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Summary Dysfunction of noradrenergic (NA) neurons is associated with a number of neuronal disorders. Diverse neuronal subtypes can be generated by direct reprogramming. However, it is still unknown how to convert non-neuronal cells into NA neurons. Here, we show that seven transcription factors (TFs) (Ascl1, Phox2b, AP-2α, Gata3, Hand2, Nurr1, and Phox2a) are able to convert astrocytes and fibroblasts into induced NA (iNA) neurons. These iNA neurons express the genes required for the biosynthesi...
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#1Sue HanH-Index: 1
Last. Leping ChengH-Index: 18
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Serotonergic neurons project widely in the central nervous system and regulate a variety of behaviors. Obtaining induced serotonergic neurons (iSNs) iscritical for disease modeling, drug screening and cell therapy. Here, we found that a combination of transcription factors Ascl1, Nkx2.2, Gata2, Foxa2, and Lmx1b could convert postnatal astrocytes into functional serotonergic neurons. We further found that the iSNs expressed serotonergic neuron-specific markers and exhibited similar electrophysiol...
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