Rabia Mukhtar Rana
Gyeongsang National University
Publications 3
#1Amir ZebH-Index: 5
#2Donghwan KimH-Index: 1
Last.Keun Woo LeeH-Index: 30
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Mechanistically, neurotoxic insults provoke Ca2+-mediated calpain activation, which cleaves the cytoplasmic region of membrane-embedded p35 and produces its truncated form p25. Upon physical interaction, cyclin-dependent kinase 5 (Cdk5) and p25 forms hyperactivated Cdk5/p25 complex and causes severe neuropathological aberrations including hyperphosphorylated tau-mediated neurofibrillary tangles formation, Alzheimer’s symptoms, and neuronal death. Therefore, the inhibition of Cdk5/p25 complex may...
#1Raj Kumar (Gyeongsang National University)H-Index: 5
#2Saravanan Parameswaran (Gyeongsang National University)H-Index: 1
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
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Abstract Prolyl oligopeptidase (POP) is a potential therapeutic target for treatment of several neurological disorders and α-synucleinopathies including Parkinson's disease. Most of the known POP inhibitors failed in the clinical trials due to poor pharmacokinetic properties and blood-brain impermeability. Therefore, a training set of 30 structurally diverse compounds with a wide range of inhibitory activity against POP was used to generate a quantitative pharmacophore model, Hypo 3, to identify...
1 CitationsSource
#1Rabia Mukhtar RanaH-Index: 1
#2Shailima RampoguH-Index: 7
Last.Keun Woo LeeH-Index: 30
view all 11 authors...
Dihydrofolate reductase (DHFR) is an essential cellular enzyme and thereby catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF). In cancer medication, inhibition of human DHFR (hDHFR) remains a promising strategy, as it depletes THF and slows DNA synthesis and cell proliferation. In the current study, ligand-based pharmacophore modeling identified and evaluated the critical chemical features of hDHFR inhibitors. A pharmacophore model (Hypo1) was generated from known inhibitors of D...
1 CitationsSource