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Congying Chu
King's College London
PsychologyAlcoholGeneticsSchizophreniaBiology
9Publications
2H-index
8Citations
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Publications 11
Newest
#1Gabriel RobertH-Index: 2
#2Qiang Luo (Fudan University)H-Index: 12
Last. Gunter SchumannH-Index: 51
view all 33 authors...
Importance Alcohol abuse correlates with gray matter development in adolescents, but the directionality of this association remains unknown. Objective To investigate the directionality of the association between gray matter development and increase in frequency of drunkenness among adolescents. Design, Setting, and Participants This cohort study analyzed participants of IMAGEN, a multicenter brain imaging study of healthy adolescents in 8 European sites in Germany (Mannheim, Dresden, Berlin, and...
1 CitationsSource
#1Tianye Jia (Fudan University)H-Index: 14
#2Congying Chu ('KCL': King's College London)H-Index: 2
Last. Sylvane Desrivières ('KCL': King's College London)H-Index: 25
view all 82 authors...
DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as...
4 CitationsSource
#1Alex Ing ('KCL': King's College London)H-Index: 3
#2P. Saemann (MPG: Max Planck Society)H-Index: 32
Last. Gunter SchumannH-Index: 51
view all 50 authors...
Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and exe...
Source
#1Evangelos Evangelou (Imperial College London)H-Index: 47
#2He Gao (Imperial College London)H-Index: 18
Last. Perry M. ElliottH-Index: 154
view all 98 authors...
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d−1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We ide...
7 CitationsSource
#1Tao YuH-Index: 5
#2Tianye Jia (Fudan University)H-Index: 14
Last. Gabriel Robert (University of Rennes)H-Index: 2
view all 41 authors...
Abstract Objective Cannabis consumption during adolescence has been reported as a risk-factor for psychotic-like experiences (PLEs) and schizophrenia. However, brain developmental processes associated with cannabis-related PLEs are still ill-described. Method 706 adolescents from the general population that were recruited by the IMAGEN consortium had structural MRI scans both at 14 and 19 years-old. We used deformation-based morphometry to map voxel-wise brain changes between the two time points...
Source
#1Savani BartholdyH-Index: 11
#2Owen O'DalyH-Index: 25
view all 124 authors...
Abstract Background Binge eating and other forms of disordered eating behavior (DEB) are associated with failed inhibitory control. This study investigated the neural correlates of failed inhibitory control as a potential biomarker for DEB. Methods The study used prospective longitudinal data from the European IMAGEN study adolescent cohort. Participants completed baseline assessments (questionnaires and a brain scan [functional magnetic resonance imaging]) at 14 years of age and a follow-up ass...
Source
#2Congying Chu (University of Cambridge)H-Index: 2
Last. Gunter Schumann (University of Cambridge)H-Index: 51
view all 45 authors...
1 CitationsSource
#1Nicole Tay ('KCL': King's College London)H-Index: 1
#2Christine Macare ('KCL': King's College London)H-Index: 8
Last. Gunter Schumann ('KCL': King's College London)H-Index: 51
view all 42 authors...
Objective:Psychosocial stress is a key risk factor for substance abuse among adolescents. Recently, epigenetic processes such as DNA methylation have emerged as potential mechanisms that could mediate this relationship. The authors conducted a genome-wide methylation analysis to investigate whether differentially methylated regions are associated with psychosocial stress in an adolescent population.Methods:A methylome-wide analysis of differentially methylated regions was used to examine a sampl...
1 CitationsSource
#1Evangelos EvangelouH-Index: 47
#2He GaoH-Index: 18
Last. Perry M. ElliottH-Index: 154
view all 98 authors...
#1Tianye Jia ('KCL': King's College London)H-Index: 14
#2Congying Chu ('KCL': King's College London)H-Index: 2
Last. Sylvane DesrivièresH-Index: 25
view all 78 authors...
DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as...
Source
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