Match!
Xiao Hu
Yale University
4Publications
Publications 4
Newest
Published on Apr 12, 2019in Nature Communications11.88
Xiao Hu (Yale University), Zongzhi Liu10
Estimated H-index: 10
(Yale University)
+ 17 AuthorsAnna E Eastman (Yale University)
Actin cytoskeleton is well-known for providing structural/mechanical support, but whether and how it regulates chromatin and cell fate reprogramming is far less clear. Here, we report that MKL1, the key transcriptional co-activator of many actin cytoskeletal genes, regulates genomic accessibility and cell fate reprogramming. The MKL1-actin pathway weakens during somatic cell reprogramming by pluripotency transcription factors. Cells that reprogram efficiently display low endogenous MKL1 and inhi...
Published on 2019in FEBS Letters2.67
Xiao Hu (Yale University), Anna E Eastman (Yale University), Shangqin Guo11
Estimated H-index: 11
(Yale University)
Published on Dec 11, 2018in bioRxiv
Anna E Eastman (Yale University), Xinyue Chen1
Estimated H-index: 1
(Yale University)
+ 6 AuthorsShangqin Guo11
Estimated H-index: 11
(Yale University)
Periodicity is a fundamental property of biological oscillators such as the mitotic cell cycle. In this context, periodicity refers to the time interval between the same phases of two consecutive cell cycles. The length of this interval, or the cell cycle speed, varies widely depending on cell type and the pathophysiological conditions. The relevance of cell cycle speed in various biological contexts has not been well-studied, partially due to the lack of experimental approaches that capture thi...
Published on Nov 30, 2018in bioRxiv
Xinyue Chen1
Estimated H-index: 1
(Yale University),
Amaleah Hartman1
Estimated H-index: 1
(Yale University)
+ 4 AuthorsShangqin Guo11
Estimated H-index: 11
(Yale University)
Cancer is a hyper-proliferative clonal disease. Whether the proliferative state originates from the cell-of-origin or emerges later remains elusive. By tracking de novo transformation from normal hematopoietic progenitors expressing an acute myeloid leukemia (AML) oncogene MLL-AF9, we reveal that the cell cycle rate heterogeneity among granulocyte-macrophage progenitors (GMPs) determines their probability of transformation. An intrinsic fast cell cycle kinetics at the time of oncogene expression...
Published on Nov 28, 2018in bioRxiv
Amaleah Hartman1
Estimated H-index: 1
(Yale University),
Xiao Hu (Yale University)+ 3 AuthorsShangqin Guo11
Estimated H-index: 11
(Yale University)
While Yes-associated protein (YAP) antagonizes pluripotency during early embryogenesis, it has also been shown to promote stemness of multiple stem cell types, including pluripotent stem cells. Whether cellular context underlies these distinct functions of YAP in pluripotency remains unclear. Here, we establish that depending on the specific cells in which it is expressed, YAP exhibits opposing effects on pluripotency induction from somatic cells. Specifically, YAP inhibits pluripotency inductio...
Published on 2017in Blood16.56
Xinyue Chen1
Estimated H-index: 1
(Yale University),
Xiao Hu (Yale University)+ 3 AuthorsShangqin Guo11
Estimated H-index: 11
(Yale University)
The conventional view of oncogenesis posits that driver mutations, when present in appropriate cell types, initiate malignant transformation. At the apex of the differentiation hierarchy, stem cells, such as hematopoietic stem cells, have been suggested to be the cell-of-origin for a variety of hematopoietic malignancies. However, since the mutation bearing hematopoietic stem cells can differentiate to give rise to downstream progeny, it suggests the possibility that some of the downstream cells...
Published on Jul 1, 2016in Cell Death and Disease5.96
J Yao1
Estimated H-index: 1
,
L Zhang1
Estimated H-index: 1
+ 10 AuthorsJ T Y Lau1
Estimated H-index: 1
Detailed understanding of the mechanistic steps underlying tumor initiation and malignant progression is critical for insights of potentially novel therapeutic modalities. Cellular reprogramming is an approach of particular interest because it can provide a means to reset the differentiation state of the cancer cells and to revert these cells to a state of non-malignancy. Here, we investigated the relationship between cellular differentiation and malignant progression by the fusion of four indep...
Published on Apr 1, 2014in Cell Stem Cell21.46
Xiao Hu2
Estimated H-index: 2
(LMB: Laboratory of Molecular Biology),
Lei Zhang27
Estimated H-index: 27
(LMB: Laboratory of Molecular Biology)
+ 15 AuthorsWei Liu4
Estimated H-index: 4
(LMB: Laboratory of Molecular Biology)
Summary Tet-mediated DNA oxidation is a recently identified mammalian epigenetic modification, and its functional role in cell-fate transitions remains poorly understood. Here, we derive mouse embryonic fibroblasts (MEFs) deleted in all three Tet genes and examine their capacity for reprogramming into induced pluripotent stem cells (iPSCs). We show that Tet-deficient MEFs cannot be reprogrammed because of a block in the mesenchymal-to-epithelial transition (MET) step. Reprogramming of MEFs defic...
Published on Jan 1, 2014
Run-Rui Zhang2
Estimated H-index: 2
,
Gui-Fang Xu3
Estimated H-index: 3
+ 13 AuthorsXianlong Li8
Estimated H-index: 8
Published on Dec 1, 2013in Nature Genetics25.45
Jiekai Chen17
Estimated H-index: 17
,
Lin Guo7
Estimated H-index: 7
+ 19 AuthorsZhiwei Zhou3
Estimated H-index: 3
Guo-Liang Xu, Duanqing Pei and colleagues show that during induced pluripotent cell reprogramming Tet1 regulates 5-hydroxymethylcytosine levels at loci critical for mesenchymal-to-epithelial transition in a vitamin C–dependent fashion. They also show that Tet1 either enhances or inhibits somatic cell reprogramming, depending on the absence or presence of vitamin C, respectively.
1