James O Early
Royal College of Surgeons in Ireland
Innate immune systemProinflammatory cytokineInflammationCircadian clockImmune system
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#1James O Early (RCSI: Royal College of Surgeons in Ireland)H-Index: 1
#2Deepthi MenonH-Index: 12
Last. Annie Curtis (RCSI: Royal College of Surgeons in Ireland)
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A variety of innate immune responses and functions are dependent on time of day, and many inflammatory conditions are associated with dysfunctional molecular clocks within immune cells. However, the functional importance of these innate immune clocks has yet to be fully characterized. NRF2 plays a critical role in the innate immune system, limiting inflammation via reactive oxygen species (ROS) suppression and direct repression of the proinflammatory cytokines, IL-1β and IL-6. Here we reveal tha...
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