Zee Upton
Agency for Science, Technology and Research
Publications 11
#1Aleksandra Shedoeva (Agency for Science, Technology and Research)
#2David Leavesley (Agency for Science, Technology and Research)
Last.Chen Fan (Agency for Science, Technology and Research)H-Index: 1
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Cutaneous wound healing is the process by which skin repairs itself. It is generally accepted that cutaneous wound healing can be divided into 4 phases: haemostasis, inflammation, proliferation, and remodelling. In humans, keratinocytes re-form a functional epidermis (reepithelialization) as rapidly as possible, closing the wound and reestablishing tissue homeostasis. Dermal fibroblasts migrate into the wound bed and proliferate, creating “granulation tissue” rich in extracellular matrix protein...
#1Chen Fan (Agency for Science, Technology and Research)H-Index: 1
#2Lay Keng Priscilla Lim (Agency for Science, Technology and Research)
Last.David Leavesley (Agency for Science, Technology and Research)
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Abstract Pathological scarring is an intractable problem for both patients and clinicians. A major obstacle for the development of scar remediation therapies is the paucity of suitable in vivo and in vitro models. The “Scar-in-a-jar” model was previously established by our colleagues based on the principle of “Macromolecular crowding”. This has been demonstrated to be an extracellular matrix-rich in vitro model offering a novel tool for studies related to the extracellular matrix. In the study r...
#1M. Andrade (Manipal University)
#2Kapaettu Satyamoorthy (Manipal University)H-Index: 17
Last.D. Van Lonkhuyzen (QUT: Queensland University of Technology)
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#1Zee Upton (Agency for Science, Technology and Research)H-Index: 1
#2Melissa L. Fernandez (Agency for Science, Technology and Research)H-Index: 1
1 CitationsSource
#1Chen Fan (Agency for Science, Technology and Research)H-Index: 1
#2Xufang Zhang (SYSU: Sun Yat-sen University)H-Index: 1
Last.Zee Upton (Agency for Science, Technology and Research)H-Index: 1
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AbstractContext: Shikonin (SHI), an active component extracted from Radix Arnebiae, has been reported to possess anti-inflammatory properties in various cells. However, its effect on lipopolysaccharide (LPS)-stimulated human periodontal ligament cells (hPDLCs) is unknown.Objective: To investigate the effects of SHI on the expression of inflammatory related cytokines in LPS-stimulated hPDLCs.Materials and methods: The effects of SHI (0.125, 0.25, 0.5, 1, and 2 μg/mL) on hPDLCs proliferation for 1...
5 CitationsSource
#1Keith HardingH-Index: 55
#2Pat AldonsH-Index: 1
Last.Zee UptonH-Index: 1
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Hard-to-heal leg ulcers are a major cause of morbidity in the elderly population. Despite improvements in wound care, some wounds will not heal and they present a significant challenge for patients and health care providers. A multi-centre cohort study was conducted to evaluate the effectiveness and safety of a synthetic, extracellular matrix protein as an adjunct to standard care in the treatment of hard-to-heal venous or mixed leg ulcers. Primary effectiveness criteria were (i) reduction in wo...
#1Dario StuparH-Index: 3
#2Tony J. ParkerH-Index: 7
Last.Melissa L. FernandezH-Index: 1
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#1Zee UptonH-Index: 1
#2Gary K. ShooterH-Index: 9
Last.Michael StaceyH-Index: 16
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anticancer potential. Fenofibrate is a potent agonist of peroxisome proliferator activated receptor alpha (PPARa) that can switch energy metabolism from glycolysis to fatty acid b-oxidation, and has low systemic toxicity. Fenofibrate also attenuates IGF-I-mediated cellular responses, which could be relevant in the process of glioblastoma cell dispersal. Methods: The effects of fenofibrate on glioma cell motility, IGF-I receptor (IGF-IR) signaling, PPARa activity, reactive oxygen species (ROS) me...