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Nattaphong Rattanavirotkul
Western General Hospital
HeterochromatinNotch signaling pathwaySenescenceBiologyCell biology
6Publications
1H-index
4Citations
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Publications 7
Newest
#1Kristina Kirschner (Glas.: University of Glasgow)H-Index: 13
#2Nattaphong Rattanavirotkul (MU: Mahidol University)H-Index: 1
Last. Tamir Chandra (Edin.: University of Edinburgh)H-Index: 17
view all 4 authors...
Senescence is a tumour suppressor mechanism which is cell-intrinsically activated in the context of cellular stress. Senescence can further be propagated to neighbouring cells, a process called secondary senescence induction. Secondary senescence was initially shown as a paracrine response to the secretion of cytokines from primary senescent cells. More recently, juxtacrine Notch signalling has been implicated in mediating secondary senescence induction. Primary and secondary senescent induction...
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#1Michael Chiang (Edin.: University of Edinburgh)H-Index: 2
#2Davide Michieletto (University of Bath)H-Index: 10
Last. Tamir Chandra (Western General Hospital)H-Index: 17
view all 7 authors...
Summary Lamina-associated domains (LADs) cover a large part of the human genome and are thought to play a major role in shaping the nuclear architectural landscape. Here, we perform polymer simulations, microscopy, and mass spectrometry to dissect the roles played by heterochromatin- and lamina-mediated interactions in nuclear organization. Our model explains the conventional organization of heterochromatin and euchromatin in growing cells and the pathological organization found in oncogene-indu...
4 CitationsSource
#1Michael ChiangH-Index: 2
#2Davide MichielettoH-Index: 10
Last. Tamir ChandraH-Index: 17
view all 7 authors...
Source
#1Yee Voan Teo (Brown University)H-Index: 3
#2Nattaphong Rattanavirotkul (Edin.: University of Edinburgh)H-Index: 1
Last. Tamir Chandra (Edin.: University of Edinburgh)H-Index: 17
view all 15 authors...
Summary Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene activation that can be transmitted to neighboring cells through secreted factors of the senescence-associated secretory phenotype (SASP). Currently, primary and secondary senescent cells are not considered functionally distinct endpoints. Using single-cell analysis, we observed two distinct transcriptional endpoints, a primary endpoint marked by Ras and a secondary endpoint marked by Notch activation. We find t...
Source
#1Tamir ChandraH-Index: 17
Last. Kristina KirschnerH-Index: 13
view all 3 authors...
Source
#1Yee Voan Teo (Brown University)H-Index: 3
#2Nattaphong Rattanavirotkul (Edin.: University of Edinburgh)H-Index: 1
Last. Tamir Chandra (Edin.: University of Edinburgh)H-Index: 17
view all 14 authors...
Oncogene induced senescence (OIS) is a tumour suppressive response to oncogene activation that can be transmitted to neighbouring cells through secreted factors of the senescence associated secretory phenotype (SASP). Using single-cell transcriptomics we observed two distinct endpoints, a primary marked by Ras and a secondary by Notch. We find that secondary senescence in vitro and in vivo requires Notch, rather than SASP alone as previously thought. Currently, primary and secondary senescent ce...
Source
#1Michael Chiang (Edin.: University of Edinburgh)H-Index: 2
#2Davide Michieletto (Edin.: University of Edinburgh)H-Index: 10
Last. Tamir Chandra (Edin.: University of Edinburgh)H-Index: 17
view all 7 authors...
Lamina-associated domains (LADs) cover a large part of the human genome and are thought to play a major role in shaping the nuclear architectural landscape. Here, we use simulations based on concepts from polymer physics to dissect the roles played by heterochromatin- and lamina-mediated interactions in nuclear organisation. Our model explains the conventional organisation of heterochromatin and euchromatin in growing cells, as well as the pathological organisation found in oncogene-induced sene...
3 CitationsSource
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