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Tatiana Shtam
Petersburg Nuclear Physics Institute
10Publications
2H-index
14Citations
Publications 10
Newest
#1D. V. Lebedev (Petersburg Nuclear Physics Institute)H-Index: 6
Last.Vladimir V. EgorovH-Index: 11
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Abstract This work focuses on the study of multimeric alpha-lactalbumin oleic acid and lactoferrin oleic acid complexes. The purpose of the research is to study possible mechanisms involved in their pro-apoptotic activities, as seen in some tumor cell cultures. Complexes featuring oleic acid (OA) with human alpha-lactalbumin (hAl) or with bovine alpha-lactalbumin (bAl), and human lactoferrin (hLf) were investigated using small-angle neutron scattering (SANS). It was shown that while alpha-lactal...
1 CitationsSource
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#1D. V. Lebedev (Petersburg Nuclear Physics Institute)H-Index: 6
#2Yana A. Zabrodskaya (Petersburg Nuclear Physics Institute)H-Index: 3
Last.Vladimir V. Egorov (Petersburg Nuclear Physics Institute)H-Index: 11
view all 17 authors...
This work focuses on the study of multimeric alpha-lactalbumin oleic acid and lactoferrin oleic acid complexes. The purpose of the research is to study possible mechanisms involved in their pro-apoptotic activities, as seen in some tumor cell cultures. Complexes featuring oleic acid (OA) with human alpha-lactalbumin (hAl) or with bovine alpha-lactalbumin (bAl), and human lactoferrin (hLf) were investigated using small-angle neutron scattering (SANS). It was shown that while alpha-lactalbumin pro...
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#1A. V. Volnitskiy (Petersburg Nuclear Physics Institute)H-Index: 1
#2Tatiana Shtam (Petersburg Nuclear Physics Institute)H-Index: 2
Last.Michael V. Filatov (Petersburg Nuclear Physics Institute)H-Index: 9
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Malignant transformation is associated with loss of cell differentiation, anaplasia. Transcription factors gli, required for embryonic development, may be involved in this process. We studied the activity of transcription factors gli in high-grade gliomas and their role in maintenance of stem cell state and glioma cell survival. 20 glioma cell lines and a sample of a normal adult brain tissue were used in the present study. We found the expression of gli target genes, including GLI1 and FOXM1, i...
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#1Tatiana Shtam (Petersburg Nuclear Physics Institute)H-Index: 2
#2Stanislav N. Naryzhny (Academy of Medical Sciences, United Kingdom)H-Index: 13
Last.A. V. MalekH-Index: 4
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Purpose The interaction between malignant cells and surrounding healthy tissues is a critical factor in the metastatic progression of breast cancer (BC). Extracellular vesicles, especially exosomes, are known to be involved in inter-cellular communication during cancer progression. In the study presented herein, we aimed to evaluate the role of circulating plasma exosomes in the metastatic dissemination of BC and to investigate the underlying molecular mechanisms of this phenomenon.
7 CitationsSource
Extracellular vesicles (EV) are secreted by cells of multicellular organisms. EV mediate specific mode of intercellular communication by “horizontal” exchange of substances and information. This phenomenon seems to have an essential biological significance and became a subject of intensive research. Biogenesis, structural and functional EV features are usually studied in vitro. Several methods of EV isolation from cell culture medium are currently used; however, selection of a particular method ...
1 CitationsSource
#1Tatiana ShtamH-Index: 2
#2Stanislav N. Naryzhny (Petersburg Nuclear Physics Institute)H-Index: 13
Last.A. V. MalekH-Index: 4
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Background: Exosomes and other types of extracellular vesicles present an important component of circulating plasma. Exosomes released by endothelial and blood cells account for majority of plasma exosomal population, exosomes secreted by other cells might cross tissue-plasma barrier and reach circulating plasma as well. Definitely, exosomes of different cellular origin are different by content and function. However, exosomal surface membrane interacts with plasma components. This interaction ma...
1 CitationsSource
#1Tatiana ShtamH-Index: 2
#2R. SamsonovH-Index: 4
Last.A. V. MalekH-Index: 4
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Exosomes are membrane-bound, intercellular communication shuttle vesicles that are defined by their endocytic origin and size range of 30–120 nm. Secreted by nearly all mammalian cell types and present in bodily fluids, exosomes confer messages between cells, by transporting functionally relevant proteins, nucleic acids, and lipids. The capability of tumor exosomes to house tumorigenic information and induce cellular responses that promote disease pathogenesis make tumor exosomes an attractive t...
4 CitationsSource
#1R. A. Kovalev (Kurchatov Institute)H-Index: 3
#2Tatiana Shtam (Kurchatov Institute)H-Index: 2
Last.M. V. Filatova (Saint Petersburg State Polytechnic University)H-Index: 1
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The p21/Waf1 protein is one of the main regulators of cell cycle arrest and one of the best-known transcriptional targets of the TP53 protein. Here, we demonstrated that there is activation of expression of the p21/Waf1 gene when the cells were treated with sodium butyrate (NaBu), which is a natural histone deacetylase inhibitor, and investigated whether this phenomenon depends on the presence of a functionally active TP53 protein. For this purpose, we compared the effect of NaBu treatment of hu...
1 CitationsSource
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